Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Petzmann, S; Ullmann, R; Klemen, H; Renner, H; Popper, HH.
Loss of heterozygosity on chromosome arm 11q in lung carcinoids.
Hum Pathol. 2001; 32(3):333-338
Doi: 10.1053/hupa.2001.22762
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- Führende Autor*innen der Med Uni Graz
- Petzmann Susanne
- Popper Helmuth
- Co-Autor*innen der Med Uni Graz
- Klemen Huberta
- Renner Heiko
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- Abstract:
- Neuroendocrine lung tumors such as typical carcinoid, atypical carcinoid, small-cell lung carcinoma, and large-cell neuroendocrine carcinoma represent a variable group with different biologic characteristics and unclear genetical relationships. We investigated the pattern of allelic loss on chromosome arm 11q in 20 sporadic carcinoid tumors of the lung using 10 microsatellite markers. Loss of heterozygosity was found in 13 of 20 tumors. In 5 of 9 typical carcinoids, 3 distinct regions of allelic loss were identified: 11q13.1 (D11S1883), 11q14.3-11q21 (D11S906), and 11q25 (D11S910). Atypical carcinoids showed loss of heterozygosity at 4 different regions: the first, most proximal region at 11q13 between markers PYGM and D11S937; the second at 11q14.3-11q21 (D11S906); and the third and fourth defined by markers D11S939 (11q23.2-23.3) and D11S910 (11q25). However, the region 11q13 harboring the MEN1 gene was more frequently affected in atypical carcinoids (7 of 11) than in typical carcinoids (2 of 9). The high rate of allelic losses within chromosomal region 11q13 in atypical carcinoids emphasizes the importance of this region for tumor development. We also recognized that more aggressive atypical carcinoids defined by high mitotic counts, vascular invasion, and/or organ metastasis are combined with increased allelic losses. HUM PATHOL 32:333-338.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Alleles -
- Carcinoid Tumor - genetics Carcinoid Tumor - pathology
- Chromosomes, Human, Pair 11 -
- Female -
- Humans -
- Loss of Heterozygosity -
- Lung Neoplasms - genetics Lung Neoplasms - pathology
- Lymphatic Metastasis -
- Male -
- Microsatellite Repeats -
- Middle Aged -
- Mitosis -
- Neoplasm Metastasis -
- Prognosis -
- Find related publications in this database (Keywords)
- neuroendocrine lung tumors
- lung carcinoid
- loss of heterozygosity on chromosome 11q
- genetic alterations