Medizinische Universität Graz - Research portal
Selected Publication:
Baranton, G; Seinost, G; Theodore, G; Postic, D; Dykhuizen, D.
Distinct levels of genetic diversity of Borrelia burgdorferi are associated with different aspects of pathogenicity.
Res Microbiol. 2001; 152(2):149-156
Doi: 10.1016%2FS0923-2508%2801%2901186-X
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- Co-authors Med Uni Graz
- Seinost Gerald
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- Abstract:
- Different species of pathogenic Borrelia show different symptoms and tick vector specificity. Even within regions where only one species is found, Lyme disease progresses very differently from one patient to another. Since Borrelia shows very little recombination either within or between species, alleles of a gene can be used to mark clones. The ospC gene is highly variable within each species and can be used to define groups of related clones. It has been previously shown that only four out of seventeen ospC groups of Borrelia burgdorferi sensu stricto cause invasive forms of the disease. Other groups cause erythema migrans, a skin rash at the site of the tick bite, but not invasive disease, while still other groups seem to be nonpathogenic to humans. In this study we extend the analysis of the ospC gene to the other pathogenic species, Borrelia garinii and Borrelia afzelii. Only two groups in B. afzelii and four groups in B. garinii cause invasive disease. Thus, only ten out of the 58 defined ospC groups cause invasive and presumably chronic Lyme disease.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Antigens, Bacterial -
- Antigens, Surface - genetics
- Bacterial Outer Membrane Proteins - genetics
- Bacterial Vaccines - genetics
- Borrelia - genetics
- Borrelia burgdorferi Group - genetics
- Erythema Chronicum Migrans - microbiology
- Genes, Bacterial - microbiology
- Humans - microbiology
- Lipoproteins - microbiology
- Lyme Disease - microbiology
- Lyme Disease Vaccines - genetics
- Phylogeny - genetics
- Ticks - microbiology
- Variation (Genetics) - microbiology
- Virulence - microbiology
- Find related publications in this database (Keywords)
- genetic diversity
- Borrelia burgdorferi
- Lyme disease
- pathogenicity
- OspC