Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Knerr, I; Huppertz, B; Weigel, C; Dötsch, J; Wich, C; Schild, RL; Beckmann, MW; Rascher, W.
Endogenous retroviral syncytin: compilation of experimental research on syncytin and its possible role in normal and disturbed human placentogenesis.
MOL HUM REPROD 2004 10: 581-588.
Doi: 10.1093/molehr/gah070
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- Co-Autor*innen der Med Uni Graz
- Huppertz Berthold
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- Abstract:
- Placental syncytin was first described in the year 2000 as a fusogenic glycoprotein originally derived from a human endogenous retroviral envelope gene. Although the presence of stable integrated retroviral elements within the human genome has been known for many years, their biological significance is still obscure and has usually been designated as irrelevant or even harmful. Syncytin, however, demonstrates tissue-specific expression and distinctive receptor interaction during trophoblast cell differentiation and syncytium formation. These findings indicate an involvement of syncytin in the development of the human placenta. Disturbances in placental architecture leading to severe placental dysfunction, such as pre-eclampsia, may therefore be discussed as a consequence of an altered syncytin system. We evaluate the hypothesis that syncytin is essential for human placenta formation and may also have played an important role in human placental evolution.
- Find related publications in this database (using NLM MeSH Indexing)
- Amino Acid Transport System ASC - metabolism
- Cell Differentiation - metabolism
- Endogenous Retroviruses - genetics
- Evolution - genetics
- Female - genetics
- Gene Products, env - genetics
- Gestational Age - genetics
- Humans - genetics
- Immune Tolerance - genetics
- Placenta - chemistry
- Pregnancy - chemistry
- Pregnancy Proteins - genetics
- Research Support, Non-U.S. Gov't - genetics
- Find related publications in this database (Keywords)
- ASCT2
- human endogenous retrovirus
- placenta
- syncytin
- syncytiotrophoblast