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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Meurer, B; Neumaier-Wagner, PM; Reister, F; Huppertz, B; Rath, W.
Increased expression of iNOS in macrophages of the placental bed of women with severe Preeclampsia
GEBURTSH FRAUENHEILK 2004 64: 930-935. Doi: 10.1055/s-2004-821178
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Co-Autor*innen der Med Uni Graz: Huppertz Berthold
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Abstract:: Purpose: Impaired invasion of uteroplacental arteries by extravillous trophoblast cells is a key pathogenetic mechanism of preeclampsia. In this context proapoptotic effects (secretion of TNF-alpha; tryptophan depletion) of macrophages in and around the wall of spiral arteries may play a crucial role. The aim of this study was to assess whether these macrophages in the placental bed of women with severe preeclampsia express NO, which is known to trigger apoptosis in other tissues. Material and Methods: Serial cryostate and paraffin sections were obtained using placental bed biopsies of preeclamptic patients (n = 7; spiral arteries n = 42) and normotensive healthy controls (n = 8; spiral arteries n = 57) and immunostained for trophoblast cells, macrophages and iNOS. Results: a) The number of macrophages in the media of spiral arteries (p = 0.02) as well as the iNOS expression in these cells (p < 0.001) was significantly increased in preeclamptic women compared to normotensive controls. b) Placental bed biopsies of normotensive controls showed significantly less infiltrates of macrophages around the spiral arteries than biopsies obtained from preeclamptic women (p = 0.001). These infiltrates revealed an iNOS expression only in cases of preeclampsia (p < 0.001). Conclusion: Our data suggest that the impaired endovascular invasion of uteroplacental arteries by extravillous trophoblast cells in preeclampsia could be triggered by apoptotic effects via a significantly increased NO synthesis controlled by macrophages in and around the spiral arteries in the placental bed.
Find related publications in this database (Keywords): preeclampsia; placental bed; macrophages; iNOS; apoptosis