Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Frazier, CG; Shah, SH; Armstrong, PW; Bhapkar, MV; McGuire, DK; Sadowski, Z; Kristinsson, A; Aylward, PE; Klein, WW; Weaver, WD; Newby, LK; SYMPHONY and the Second SYMPHONY Investigators.
Prevalence and management of hypertension in acute coronary syndrome patients varies by sex: observations from the Sibrafiban versus aspirin to Yield Maximum Protection from ischemic Heart events postacute cOroNary sYndromes (SYMPHONY) randomized clinical trials.
Am Heart J. 2005; 150(6):1260-1267
Doi: 10.1016/j.ahj.2005.08.004
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Klein Werner
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- Abstract:
- BACKGROUND: Hypertension affects 1 billion individuals worldwide and is an independent risk factor for death after acute coronary syndromes (ACS). METHODS: We examined the prevalence and medical treatment of hypertension among 15,904 ACS patients randomized in the SYMPHONY and 2nd SYMPHONY trials. Analyses were performed overall and according to sex for the United States and across international practice. Multivariable models identified factors associated with use of antihypertensive medication classes and examined the association of hypertension and sex with mortality. RESULTS: In the United States, hypertension was more prevalent in women than in men, overall (63% vs 50%) and within every decile of age. Hypertensive women more often received calcium-channel blockers (35% vs 30%) and diuretics (33% vs 19%) and less often received beta-blockers (51% vs 57%). Angiotensin-converting enzyme inhibitor use was similar (35% vs 34%). Women received multiple agents more frequently than did men: 2 agents, 35% vs 30%; > or = 3 agents, 16% vs 13%. Female sex independently predicted drug-class use only for diuretics. Mortality was higher in hypertensive women than in hypertensive men; after multivariable adjustment, mortality was similar without evidence of a differential association between hypertension and mortality according to sex. Although there was international variation in the use of individual classes of agents, the overall findings by sex were similar across regions. CONCLUSION: Hypertension is more prevalent in women than in men with ACS, and its medical management varies by sex, but its association with mortality is similar. Opportunities exist to improve medical therapy and outcomes in women with hypertension.
- Find related publications in this database (using NLM MeSH Indexing)
- Acute Disease -
- Aged -
- Angina, Unstable - drug therapy
- Aspirin - administration and dosage
- Chemistry, Pharmaceutical - administration and dosage
- Coronary Disease - complications
- Female - complications
- Humans - complications
- Hypertension - drug therapy
- Male - drug therapy
- Middle Aged - drug therapy
- Myocardial Ischemia - drug therapy
- Platelet Aggregation Inhibitors - administration and dosage
- Sex Characteristics - administration and dosage