Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Schaller, HC; Schaupp, L; Bodenlenz, M; Wilinska, ME; Chassin, LJ; Wach, P; Vering, T; Hovorka, R; Pieber, TR.
On-line adaptive algorithm with glucose prediction capacity for subcutaneous closed loop control of glucose: evaluation under fasting conditions in patients with Type 1 diabetes.
DIABETIC MED. 2006; 23(1): 90-93.
Doi: 10.1111/j.1464-5491.2006.01695.x
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Co-Autor*innen der Med Uni Graz
- Pieber Thomas
- Schaupp Lukas
- Weiss Manfred
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- AIMS: To evaluate an algorithm with glucose prediction capacity and continuous adaptation of patient parameters-a model predictive control (MPC) algorithm-to control blood glucose concentration during fasting conditions in patients with Type 1 diabetes. In the subcutaneous (sc) route within a closed loop system. METHODS: Paired experiments were performed in six patients. Over 8 h the MPC algorithm was used to control glucose with s.c. insulin administration and two different glucose monitoring protocols: first, the algorithm was provided with intravenous (i.v.) glucose values for insulin dosage calculation directly (i.v.-s.c. route). Then, in the second experiment, i.v. glucose values were fed to the MPC with a delay of 30 min to simulate s.c. glucose measurements ('s.c.'-s.c. route). In both experiments plasma glucose, insulin dosage, and serum insulin levels were analysed. RESULTS: Glucose concentration was brought from hyper- to normoglycaemia and kept in the physiological range (6-7 mmol/l) with both routes in all subjects. Mean glucose concentration reached the threshold of 7 mmol/l approximately 2 (i.v.-s.c. route) and 3 ('s.c.'-s.c. route) hours after the start of glucose control with the MPC. During the last 2 h of automated glucose control, mean glucose concentration was 6.3 +/- 0.2 mmol/l and 6.6 +/- 0.3 mmol/l for i.v.-s.c. and 's.c.'-s.c. route, respectively. Glucose concentration, insulin doses, and serum insulin levels did not differ significantly between routes (P > 0.05). CONCLUSIONS: The MPC algorithm is suitable for glucose control during fasting within an extracorporeal artificial beta-cell in the subcutaneous route Type 1 diabetic patients.
- Find related publications in this database (using NLM MeSH Indexing)
- Administration, Cutaneous -
- Algorithms -
- Blood Glucose - analysis
- Computer Simulation - analysis
- Diabetes Mellitus, Type 1 - blood
- Drug Administration Schedule - blood
- Fasting - blood
- Female - blood
- Humans - blood
- Insulin - administration and dosage
- Insulin Infusion Systems - administration and dosage
- Male - administration and dosage
- Models, Biological - administration and dosage
- Find related publications in this database (Keywords)
- algorithms
- artificial beta-cell
- continuous subcutaneous insulin infusion
- glucose control
- glucose monitoring