Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

Reich, O; Pickel, H; Lahousen, M; Tamussino, K; Winter, R.
Cervical intraepithelial neoplasia III: long-term outcome after cold-knife conization with clear margins.
Obstet Gynecol. 2001; 97(3):428-430 Doi: 10.1016%2FS0029-7844%2800%2901174-1
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Führende Autor*innen der Med Uni Graz: Reich Olaf
Co-Autor*innen der Med Uni Graz: Lahousen Manfred; Tamussino Karl; Winter Raimund
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Abstract:: OBJECTIVE: To evaluate the long-term outcome of patients with severe cervical intraepithelial neoplasia or squamous cell carcinoma in situ (CIN III) after cold-knife conization with clear margins. METHODS: A total of 4417 women (mean age 36, range 18-72 years) with histologically confirmed CIN III had cold-knife conization with clear margins at our institution between 1970 and 1994. All patients were followed up with colposcopy, cytology, and pelvic examination for a mean of 18 years (range 5-30years). RESULTS: New high-grade squamous intraepithelial lesions (SILs) (CIN II and III) developed in 15 (0.35%) patients (mean age 35, range 25-65 years) after a median of 107 (range 40-201) months. A total of 4402 (99.65%) patients (mean age 36, range 18-72 years) were free of high-grade SILs after a mean follow-up of 18 (range 5-30) years. High-grade glandular intraepithelial lesions developed in two (0.05%) patients 14 and 17 years after conization. Twelve (0.3%) patients had metachronous vulvar intraepithelial neoplasia (VIN) grade III or vaginal intraepithelial neoplasia (VAIN) grade III, and one (0.02%) patient had invasive vaginal carcinoma 10 years after conization. CONCLUSION: Cold-knife conization with clear margins was an adequate method to definitively treat CIN III.
Find related publications in this database (using NLM MeSH Indexing): Adolescent -; Adult -; Aged -; Austria - epidemiology; Carcinoma in Situ - mortality; Carcinoma, Squamous Cell - mortality; Cervical Intraepithelial Neoplasia - mortality; Conization - methods; Disease-Free Survival - methods; Female - methods; Humans - methods; Longitudinal Studies - methods; Medical Records - methods; Middle Aged - methods; Neoplasm Recurrence, Local - mortality; Treatment Outcome - mortality; Uterine Cervical Neoplasms - mortality