Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Boes, U; Wallner, S; Wascher, TC.
Acute effects of nicorandil on glucose tolerance in subjects with borderline fasting blood glucose levels.
Wien Klin Wochenschr. 2001; 113(3-4):127-129
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- Führende Autor*innen der Med Uni Graz
- Aldenhoff Ursula
- Wascher Thomas
- Co-Autor*innen der Med Uni Graz
- Holasek Sandra Johanna
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- Abstract:
- The acute effect of the anti-ischemic potassium channel opener nicorandil on glucose tolerance and post-challenge insulin levels was investigated in 11 subjects (6 males and 5 females, age 59 +/- 2 years) with borderline fasting blood glucose in a single blinded randomised study. All participants were submitted to two oral glucose tolerance tests in randomised order, once without any premedication and once 30 minutes after oral administration of 20 mg nicorandil. This single dose of nicorandil significantly increased blood glucose levels at 120 minutes (173 +/- 16 vs. 150 +/- 11 mg/dl, p < 0.05 by ANOVA) and 180 minutes (106 +/- 11 vs. 88 +/- 7 mg/dl, p < 0.05 by ANOVA) after ingestion of 75 mg of glucose. Serum insulin levels were not significantly altered. In conclusion we suggest that controlled studies in patients with coronary artery disease should be performed to investigate whether long term treatment with nicorandil increases progression rates from impaired glucose tolerance to type-II diabetes and/or from normal to impaired glucose tolerance with a possibly negative impact on the course of cardiovascular disease in comparison to conventional anti-anginal drugs.
- Find related publications in this database (using NLM MeSH Indexing)
- Administration, Oral -
- Blood Glucose - analysis Blood Glucose - drug effects
- C-Peptide - blood
- Coronary Disease - drug therapy
- Fasting -
- Female -
- Glucose Tolerance Test -
- Homeostasis - drug effects
- Humans -
- Insulin - blood
- Male -
- Middle Aged -
- Nicorandil - administration and dosage Nicorandil - adverse effects Nicorandil - pharmacology
- Radioimmunoassay -
- Time Factors -
- Vasodilator Agents - administration and dosage Vasodilator Agents - adverse effects Vasodilator Agents - pharmacology
- Find related publications in this database (Keywords)
- ATP dependent potassium channel
- glucose tolerance
- coronary artery disease
- anti-anginal medication