Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Schmidt, H; Fazekas, F; Kostner, GM; van Duijn , CM; Schmidt, R.
Angiotensinogen gene promoter haplotype and microangiopathy-related cerebral damage: results of the Austrian Stroke Prevention Study.
Stroke. 2001; 32(2):405-412
Doi: 10.1161/01.STR.32.2.405
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- Führende Autor*innen der Med Uni Graz
- Schmidt Helena
- Schmidt Reinhold
- Co-Autor*innen der Med Uni Graz
- Fazekas Franz
- Kostner Gerhard
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- Abstract:
- BACKGROUND AND PURPOSE: Microangiopathy-related cerebral damage (MARCD) is a common finding in the elderly. It may lead to cognitive impairment and gait disturbances. Arterial hypertension and age are the most important risk factors. We assessed the association between MARCD and sequence alterations in the promoter region of the angiotensinogen (AGT) gene. METHODS: We studied 410 randomly selected community-dwelling individuals aged 50 to 75 years. MARCD was defined as early confluent or confluent white matter hyperintensities or lacunes on a 1.5-T MRI. The AGT promoter was analyzed by temporal temperature gradient gel electrophoresis and automated sequencing. RESULTS: We detected 4 polymorphic sites, at positions -6, -20, -153, and -218. They created 5 haplotypes, which we coded as A (-6:g, -20:a, -153:g, -218g), B (-6:a, -20:c, -153:g, -218:g), C (-6:a, -20:c, -153:a, -218:g), D (-6:a, -20:a, -153:g, -218:g), and E (-6:a, -20:a, -153:g, -218:a). MARCD was seen in 7 subjects (63.6%) carrying 2 copies of the B haplotype (B/B), in 12 subjects (38.7%) carrying 1 copy of the B haplotype in the absence of the A haplotype (B+/A-), but in only 70 subjects (19.0%) in the remaining cohort (P:<0.001). The odds ratios for the B/B and the B+/A- genotypes were 8.0 (95% CI, 2.1 to 31.1; P:=0.003) and 1.8 (95% CI, 0.8 to 4.2; P:=0.14) after adjustment for possible confounders. CONCLUSIONS: The B haplotype of the AGT promoter in the absence of the wild-type A haplotype might represent a genetic susceptibility factor for MARCD.
- Find related publications in this database (using NLM MeSH Indexing)
- Age Distribution -
- Aged -
- Angiotensins - genetics
- Austria - epidemiology
- Brain - blood supply
- Cerebral Arterial Diseases - diagnosis
- Cerebrovascular Circulation - genetics
- Cohort Studies - genetics
- Female - genetics
- Gene Frequency - genetics
- Genetic Screening - genetics
- Haplotypes - genetics
- Humans - genetics
- Hypertension - genetics
- Linkage (Genetics) - genetics
- Logistic Models - genetics
- Magnetic Resonance Imaging - genetics
- Male - genetics
- Microcirculation - pathology
- Middle Aged - pathology
- Odds Ratio - pathology
- Point Mutation - genetics
- Polymorphism, Genetic - genetics
- Promoter Regions (Genetics) - genetics
- Risk Assessment - genetics
- Sex Distribution - genetics
- Find related publications in this database (Keywords)
- angiotensins
- genetics
- magnetic resonance imaging
- small-vessel disease