Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Obermayer-Pietsch, BM; Frühauf, GE; Lipp, RW; Sendlhofer, G; Pieber, TR.
Dissociation of leptin and body weight in hyperthyroid patients after radioiodine treatment.
Int J Obes Relat Metab Disord. 2001; 25(1):115-120
Doi: 10.1038/sj.ijo.0801479
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- Führende Autor*innen der Med Uni Graz
- Obermayer-Pietsch Barbara
- Co-Autor*innen der Med Uni Graz
- Lipp Rainer
- Pieber Thomas
- Sendlhofer Gerald
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- Abstract:
- OBJECTIVE: Leptin regulates energy production rates and body weight, which are frequently altered in hyperthyroidism. Data on a possible interaction between leptin and thyroid hormones are controversial. We assessed leptin serum concentrations, BMI, proportional fat tissue mass and thyroid hormones in hyperthyroid patients in a long-term follow-up after radioiodine therapy.DESIGN: The study included 28 hyperthyroid patients (mean age 66 y) before and up to one y after radioiodine therapy. Leptin and thyroid hormones, general parameters, BMI, proportional fat tissue (PFT) measurements by DEXA and thyroid morphology were recorded. Twenty-four age-matched euthyroid individuals (mean age 63 y) served as controls.RESULTS: At baseline, leptin concentrations were significantly decreased in all hyperthyroid patients as compared to controls. One year after radioiodine therapy, 71% of the patients were euthyroid (group A) and 29% remained hyperthyroid (group B). BMI and PFT increased in both groups. While leptin concentrations remained low in group B, they normalised in group A after 6 to 12 months. Changes in leptin and thyroid hormone concentrations were positively correlated in group A patients (r = 0.49, P = 0.03) but not in patients remaining hyperthyroid.CONCLUSION: Our data indicate a dissociation in the regulation of plasma leptin and BMI as well as proportional fat tissue in hyperthyroid patients which may be attributable to differences in lean and adipose mass weight gain after radioiodine therapy or direct influences of thyroid hormones on leptin regulation.
- Find related publications in this database (using NLM MeSH Indexing)
- Absorptiometry, Photon -
- Adipose Tissue -
- Aged -
- Aged, 80 and over -
- Body Mass Index -
- Body Weight - physiology
- Bone Density -
- Female -
- Humans -
- Hyperthyroidism - blood Hyperthyroidism - physiopathology Hyperthyroidism - radiotherapy
- Iodine Radioisotopes - therapeutic use
- Leptin - blood
- Male -
- Middle Aged -
- Thyroid Hormones - blood
- Thyrotropin - blood
- Find related publications in this database (Keywords)
- leptin
- thyroid hormones
- hyperthyroidism
- radioiodine therapy
- body mass
- weight change