Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Leblhuber, F; Walli, J; Artner-Dworzak, E; Vrecko, K; Widner, B; Reibnegger, G; Fuchs, D.
Hyperhomocysteinemia in dementia.
J Neural Transm. 2000; 107(12):1469-1474
Doi: 10.1007%2Fs007020070010
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PubMed
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- Co-Autor*innen der Med Uni Graz
- Reibnegger Gilbert
- Vrecko Karoline
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- Abstract:
- Hyperhomocysteinemia is a strong risk factor for atherosclerotic vascular disease, and elevated serum homocysteine is correlated with vitamin B deficiency. In this pilot study, significantly elevated homocysteine levels were found in patients with Alzheimer's disease as well as in patients with vascular dementia, probably indicating similar pathophysiological pathways. We found significant correlations between low folic acid concentrations as well as high homocysteine concentrations and cognitive decline. Supplementation with folic acid may be an inexpensive way to reduce elevated homocysteine levels in demented patients.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Alzheimer Disease - blood Alzheimer Disease - complications Alzheimer Disease - psychology
- Cognition Disorders - blood
- Dementia, Vascular - blood Dementia, Vascular - complications Dementia, Vascular - psychology
- Female -
- Folic Acid - blood
- Homocysteine - blood
- Humans -
- Hyperhomocysteinemia - blood Hyperhomocysteinemia - complications
- Male -
- Mental Status Schedule -
- Pilot Projects -
- Reference Values -
- Regression Analysis -
- Risk Factors -
- Vitamin B 12 - blood
- Find related publications in this database (Keywords)
- homocysteine
- dementia
- Alzheimer's disease
- vascular dementia
- folic acid