Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Hinghofer-Szalkay, H; König, EM; Sauseng-Fellegger, G; Zambo-Polz, C.
Biphasic blood volume changes with lower body suction in humans.
Am J Physiol. 1992; 263(4 Pt 2):H1270-H1275
Doi: 10.1152/ajpheart.1992.263.4.H1270
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- Führende Autor*innen der Med Uni Graz
- Hinghofer-Szalkay Helmut
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- Abstract:
- We recorded blood and plasma mass density and hematocrit of antecubital venous blood in 12 subjects in the supine position before, during, and after 20-40 min of lower body subatmospheric pressure (LBNP) of -35 mmHg. Mass density values decreased during the first minutes of LBNP, indicating a transient 2.8% blood volume gain before they rose as expected. After LBNP, a pronounced further density increase, indicating a further 1.5% hemoconcentration, preceded the return toward control. This pattern suggests reflex-driven transient filtration effects. Computed mass density of fluid exchanged between blood and extravascular space was 1,007.2 +/- 4.4 milligrams (37.0 degrees C); mass density of erythrocytes remained unaltered. We conclude that sudden unloading of central pressure receptors with LBNP causes microvascular fluid gain preceding fluid loss (hemoconcentration) during LBNP, and receptor loading after LBNP additionally causes fluid loss preceding inward filtration (hemodilution) during recovery. These effects can be quantified with high-precision blood and plasma mass densitometry performed by the mechanical oscillator technique.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Blood - metabolism
- Blood Volume - metabolism
- Capillary Permeability - metabolism
- Female - metabolism
- Hematocrit - metabolism
- Humans - metabolism
- Lower Body Negative Pressure - metabolism
- Male - metabolism
- Microcirculation - metabolism
- Oscillometry - methods
- Plasma - metabolism
- Find related publications in this database (Keywords)
- Capillary Filtration
- Microcirculation
- Hematocrit
- Lower Body Subatmospheric Pressure
- Central Cardiovascular Receptors
- Autonomic Reflexes
- Mechanical Oscillator Technique