Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

Gallistl, S; Sudi, KM; Borkenstein, M; Weinhandl, G; Zotter, H; Muntean, W.
Correlation between cholesterol, soluble P-selectin, and D-dimer in obese children and adolescents.
Blood Coagul Fibrinolysis. 2000; 11(8):755-760 Doi: 10.1097%2F00001721-200012000-00009
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Führende Autor*innen der Med Uni Graz: Gallistl Siegfried
Co-Autor*innen der Med Uni Graz: Borkenstein Helmuth Martin; Muntean Eugen; Zotter Heinz
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Abstract:: Thirty-eight obese children and adolescents were investigated for a possible relation between cholesterol and markers of platelet activation, endothelial cell dysfunction, and activation of the coagulation system. Soluble P-selectin, von Willebrand factor antigen (vWf-Ag), D-dimer, and prothrombin fragment 1 + 2 (F1 + 2) were determined by enzyme-linked immunosorbent assays, and factor VIII coagulant activity (VIIIc) was measured by means of one-stage clotting assay. Cholesterol correlated significantly with log P-selectin (r = 0.43, P = 0.003) and log D-dimer (r = 0.33, P = 0.02). Cholesterol did not correlate with vWf-Ag, factor VIIIc, and F1 + 2. Log P-selectin correlated significantly with log D-dimer (r = 0.42, P = 0.003), which remained significant after adjustment for cholesterol (P = 0.02). Log D-dimer correlated significantly with F1 + 2 (r = 0.38, P = 0.01). Our study demonstrates that, in obese children and adolescents, cholesterol is significantly associated with P-selectin and D-dimer, and suggests an unfavorable intercorrelation between metabolic and hemostatic risk factors for coronary heart disease in childhood obesity.
Find related publications in this database (using NLM MeSH Indexing): Adolescent -; Blood Coagulation -; Child -; Child, Preschool -; Cholesterol - blood; Female - blood; Fibrin Fibrinogen Degradation Products - metabolism; Humans - metabolism; Male - metabolism; Obesity - blood; P-Selectin - blood
Find related publications in this database (Keywords): childhood; obesity; cholesterol; P-selectin; D-dimer