Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Muellegger, RR; Weger, W; Zoechling, N; Kaddu, S; Soyer, HP; El Shabrawi-Caelen, L; Kerl, H.
Granulomatous cheilitis and Borrelia burgdorferi: polymerase chain reaction and serologic studies in a retrospective case series of 12 patients.
Arch Dermatol. 2000; 136(12):1502-1506
Doi: 10.1001%2Farchderm.136.12.1502
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- Co-Autor*innen der Med Uni Graz
- El-Shabrawi-Caelen Laila
- Kaddu Steven
- Kerl Helmut
- Soyer Hans Peter
- Weger Wolfgang
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- Abstract:
- BACKGROUND: Granulomatous cheilitis (GC) is a chronic granulomatous inflammation of the lips of unknown etiology, which may be associated with peripheral facial nerve paralysis and/or lingua plicata (Melkersson-Rosenthal syndrome [MRS]). Borrelia burgdorferi is a spirochete that causes Lyme borreliosis, a multisystemic infectious disease with frequent occurrence of facial nerve paralysis. An etiologic role of B burgdorferi in various granulomatous diseases has been suggested. The present study was performed to examine a possible causative role of B burgdorferi for GC/MRS by B burgdorferi-specific polymerase chain reaction analysis of biopsy specimens from affected lip tissue and determination of B burgdorferi IgG and IgM serum antibodies using enzyme-linked immunosorbent assay and immunoblot tests. OBSERVATIONS: We examined a retrospective case series of 12 patients with GC/MRS from a Lyme borreliosis endemic area (median duration of disease, 8 months [range, 3-348 months]). Borrelia burgdorferi-specific DNA could not be amplified by polymerase chain reaction in any of the 12 patients. One (13%) of 8 patients tested had a serum B burgdorferi IgG response on enzyme-linked immunosorbent assay, and 2 patients (25%) had an IgM response, but immunoblot testing yielded negative results in all 8 patients. CONCLUSION: The results of the present study do not indicate that B burgdorferi has an etiologic role in GC/MRS.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Borrelia burgdorferi Group - genetics
- DNA, Bacterial - blood
- Enzyme-Linked Immunosorbent Assay - blood
- Female - blood
- Humans - blood
- Immunoglobulin G - immunology
- Immunoglobulin M - immunology
- Male - immunology
- Melkersson-Rosenthal Syndrome - microbiology
- Middle Aged - microbiology
- Polymerase Chain Reaction - microbiology
- Retrospective Studies - microbiology