Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Nassonov, EL; Samsonov, MY; Tilz, GP; Chichasova, NV; Widner, B; Demel, U; Nikiphorova, EL; Fuchs, D.
Neopterin, soluble adhesion molecules and soluble cytokine receptors correlate with disease activity in rheumatoid arthritis
PTERIDINES 2000 11: 54-59.
Doi: 10.1515/pteridines.2000.11.2.54
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- Co-Autor*innen der Med Uni Graz
- Demel Ulrike
- Tilz Gernot
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- Abstract:
- Serum concentrations of soluble intercellular adhesion molecules, sICAM-1, sICAM-3 and sP-selectin, of serum soluble cytokine receptors, sIL-2R, and sTNF-R55 and of neopterin were measured by commercially available immunoassays in 35 patients with rheumatoid arthritis (RA). Serum sICAM-1, sICAM-3 and sP-selectin were significantly elevated in patients with RA compared with healthy controls. Concentrations of sP-selectin and sICAM-3 correlated with disease activity and severity indices. sICAM-3 levels significantly correlated with sTNF-R55 and neopterin. There were significant correlations between neopterin and sIL-2R and between sTNF-R55 and sIL-2R. The measurement of sP-selectin and sICAM-3 levels in patients with RA might become useful for monitoring disease activity.
- Find related publications in this database (Keywords)
- rheumatoid arthritis
- soluble cytokine receptors
- neopterin