Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

Direkt zur Navigaton springen.
Direkt zum Inhalt springen.

Navigation/Suche

Gewählte Publikation:

Leblhuber, F; Walli, J; Tilz, GP; Demel, U; Widner, B; Fuchs, D.
Peripheral immune activation in Alzheimer's disease
PTERIDINES 2000 11: 48-53. Doi: 10.1515/pteridines.2000.11.2.48
Web of Science FullText FullText_MUG

Co-Autor*innen der Med Uni Graz: Demel Ulrike; Tilz Gernot
Altmetrics:
Dimensions Citations:
Plum Analytics:
Scite (citation analytics):
Abstract:: In fifty-four patients with Alzheimer's disease [AD (14 males, 40 females, age 77.1 +/- 7.4 years)], free of any infection and twenty-two age-matched healthy controls with normal mental status (9 males, 13 females, age 74.9 +/- 9.0 years) serum concentrations of soluble parameters of immune activation including neopterin, 55 kDa-type soluble tumor necrosis factor receptor (sTNF-R55), soluble interleukin-2 receptor (sIL-2R), immunoglobulins A, M and G, complement components C3 and C4, circulating immune complexes, and soluble CD23 as well as a panel of routine laboratory tests were determined. Compared to controls, significantly higher concentrations of sIL-2R (p < 0.01), neopterin (p < 0.01), sTNF-R55, sCD23 and IgA (all p < 0.05) were found in AD patients. Patients with greater cognitive impairment had higher concentrations of neopterin and sTNF-R55. An inverse correlation was seen between mini mental state (MMS) and sTNF-R55 (r = -0.435; p < 0.01) and neopterin (rs = -0.289; p < 0.05). Our data show increased serum concentrations of immune activation markers in patients with AD correlating with the severity of dementia. Increased neopterin concentrations together with increased sTNF-R55 and sIL-2R imply a chronic state of peripheral immune activation in the course of AD. Our data underscore previous reports on the effect of anti-inflammatory drugs in therapy and prevention of AD.
Find related publications in this database (Keywords): Alzheimer's disease; peripheral immune activation; neopterin; serum soluble cytokine receptors