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Selected Publication:
Apfelbeck, U; Hoefler, G; Neumeister, P; Fonatsch, C; Linkesch, W; Sill, H.
Extramedullary T cell lymphoblastic transformation of chronic myeloid leukaemia successfully treated with matched unrelated donor bone marrow transplantation.
BONE MARROW TRANSPLANT 2000 26: 1111-1112.
Doi: 10.1038/sj.bmt.1702665
(- Case Report)
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- Leading authors Med Uni Graz
- Apfelbeck Ute
- Sill Heinz
- Co-authors Med Uni Graz
- Höfler Gerald
- Linkesch Werner
- Neumeister Peter
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- Abstract:
- Chronic myeloid leukaemia (CML) inevitably terminates in blast crisis (BC) which is of myeloid phenotype in approximately two-thirds and B-lymphoid in one-third of patients. T cell BC is rare and associated with poor prognosis. We describe the case of a 48-year-old woman with extramedullary T cell lymphoblastic transformation. After treatment with combination chemotherapy she achieved a second chronic phase and underwent an allogeneic BMT from an HLA-matched unrelated donor. At 30 months follow-up she is still in complete molecular remission and in good clinical condition. We conclude that unrelated donor BMT should be considered as a therapeutic option for patients with extramedullary BC.
- Find related publications in this database (using NLM MeSH Indexing)
- Blast Crisis - therapy
- Bone Marrow Transplantation - therapy
- Female - therapy
- Histocompatibility Testing - therapy
- Humans - therapy
- Leukemia, Myeloid, Chronic - pathology
- Middle Aged - pathology
- T-Lymphocytes - pathology
- Find related publications in this database (Keywords)
- chronic myeloid leukaemia
- T-lymphoblastic transformation
- extramedullary blast crisis
- bone marrow transplantation