Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Kronberger, L; Steinschifter, W; Weblacher, M; Estelberger, W; Liebmann, PM; Rabl, H; Smola, M; Lax, SF; Mischinger, HJ; Schauenstein, E; Schauenstein, K.
Selective decrease of serum immunoglobulin G1 as marker for early stages of invasive breast cancer.
Breast Cancer Res Treat. 2000; 64(2):193-199
Doi: 10.1023/A:1006450205698
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Kronberger Leo
- Co-Autor*innen der Med Uni Graz
- Liebmann-Holzmann Peter
- Mischinger Hans-Jörg
- Schauenstein Konrad
- Smola Michael
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- Abstract:
- The diagnostic value of the decrease in percentage of immunoglobulin G1 (%lgG1) in breast cancer was analyzed with special emphasis on early tumor stages. IgG1 and total IgG were preoperatively measured in the sera of a total of 801 individuals using a modified quantitative affinity chromatography. Group A consisted of 174 healthy individuals of both sexes, group B of 324 female patients with benign breast disease, and group C of 303 patients with invasive and non-invasive breast cancer. Within group C, 13 patients presented with intraductal carcinoma, and 22 patients with a pT1a-tumour (diameter less than 0.5 cm). The %IgG1 values were compared among groups A, B and C. In addition, correlations were sought between %IgG1 values of group C and tumor size, stage (UICC), histopathological grade and oestrogen (ER) and progesteron receptor (PR) expression. The mean value of %IgG1 in group A was 63.3 +/- 0.5 s.e.m., in group B 57.75 +/- 0.4 s.e.m. and in group C 52.37 +/- 0.5 s.e.m. The differences of mean values were highly significant between all three groups. Sensitivity and specificity of %IgG1 to discriminate between group A and C were 75% and 87%, and between group B and C 62% and 63%, respectively. The significant decrease of %IgG1 in total serum IgG is able to distinguish patients with breast cancer of more than 5 mm in diameter from healthy controls and patients with benign breast diseases. Finally, calculated posterior probabilities revealed that within certain concentration limits %lgG1 may provide predictive information with high probabilities.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Aged, 80 and over -
- Breast Diseases - classification Breast Diseases - immunology Breast Diseases - pathology
- Breast Neoplasms - classification Breast Neoplasms - immunology Breast Neoplasms - pathology
- Carcinoma, Ductal, Breast - classification Carcinoma, Ductal, Breast - immunology Carcinoma, Ductal, Breast - pathology
- Female -
- Humans -
- Immunoglobulin G - analysis
- Middle Aged -
- Neoplasm Invasiveness -
- Neoplasm Staging - methods
- Predictive Value of Tests -
- Receptors, Progesterone - analysis
- Sensitivity and Specificity -
- Find related publications in this database (Keywords)
- affinity chromatography
- breast cancer
- immunoglobulin G subclasses
- sensitivity
- specificity
- tumor marker
- %IgG1