Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Pagel, PS; Toller, WG; Gross, ER; Gare, M; Kersten, JR; Warltier, DC.
K(ATP) channels mediate the beneficial effects of chronic ethanol ingestion.
AMER J PHYSIOL-HEART CIRC PHY 2000 279: H2574-H2579.
Doi: 10.1152/ajpheart.2000.279.5.H2574
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- Co-Autor*innen der Med Uni Graz
- Toller Wolfgang
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- Abstract:
- Chronic ingestion of low doses of ethanol protects the myocardium from ischemic injury by activating adenosine receptors and protein kinase C. We tested the hypothesis that ATP-dependent potassium (K(ATP)) channels mediate these beneficial effects. Dogs were fed with ethanol (1.5 g/kg) or water mixed with dry food twice per day for 12 wk. After they were acutely instrumented for measurement of hemodynamics, dogs received saline (vehicle) or glyburide (0.1 mg/kg iv) and were subjected to 60 min of coronary artery occlusion followed by 3 h of reperfusion. Infarct size (through triphenyltetrazolium chloride staining) was significantly (P < 0.05) reduced to 14 +/- 1% of the left ventricular area at risk in ethanol-pretreated dogs compared with controls (25 +/- 2%). Glyburide alone did not affect infarct size (25 +/- 3%) but abolished the protective effects of ethanol pretreatment (28 +/- 3%). No differences in hemodynamics or coronary collateral blood flow (through radioactive microspheres) were observed among groups. The results indicate that K(ATP) channels mediate the protective effects of chronic consumption of ethanol.
- Find related publications in this database (using NLM MeSH Indexing)
- Adenosine Triphosphate - metabolism
- Administration, Oral - metabolism
- Animals - metabolism
- Collateral Circulation - drug effects
- Coronary Circulation - drug effects
- Dogs - drug effects
- Drug Administration Schedule - drug effects
- Ethanol - administration and dosage
- Glyburide - pharmacology
- Heart - drug effects
- Hemodynamic Processes - drug effects
- Myocardial Infarction - metabolism
- Potassium Channels - metabolism
- Protein Kinase C - metabolism
- Receptors, Purinergic P1 - metabolism
- Research Support, U.S. Gov't, P.H.S. - metabolism
- Find related publications in this database (Keywords)
- myocardial infarction
- infarct size
- prolonged coronary occlusion
- myocardial ischemia