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Petru, E; Kapp, K; Poschauko, J; Pickel, H.
Primary concomitant chemo-radiotherapy for cervical carcinoma as a mew therapeutic standard replacing primary radiotherapy alone - A survey of randomized trials
GEBURTSH FRAUENHEILK 2000 60: 503-507. Doi: 10.1055/s-2000-8029
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Leading authors Med Uni Graz: Petru Edgar
Co-authors Med Uni Graz: Kapp Karin S.
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Abstract:: Objective: To review randomized trials of concomitant chemoradiotherapy in cervical cancer. Methods: Ten randomized trials including a total of 2332 patients with stage IB2 to IVA cervical cancer have been published. Eight studies addressed primary treatment and one each studied the adjuvant and neoadjuvant settings. Four of the eight trials found a significant benefit for chemoradiotherapy compared with radiotherapy only for primary treatment. Chemoradiotherapy regimens including cisplatin (with or without 5-fluorouracil) were moderately toxic and significantly more active than those including hydroxyurea or misonidazole. Similarly, chemoradiotherapy was superior to radiotherapy only in the adjuvant and neoadjuvant settings. Conclusions: Cisplatin-based chemoradiotherapy appears set to displace radiotherapy alone as the standard of care for patients with advanced cervical cancer. Which cisplatin-based regimen is the best is unclear.