Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Silberer, M; Koszik, F; Stingl, G; Aberer, E.
Downregulation of class II molecules on epidermal Langerhans cells in Lyme borreliosis.
Br J Dermatol. 2000; 143(4):786-794
Doi: 10.1046%2Fj.1365-2133.2000.03776.x
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PubMed
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- Führende Autor*innen der Med Uni Graz
- Aberer Elisabeth
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- Abstract:
- BACKGROUND: Borrelia burgdorferi can be isolated from the skin of patients with acrodermatitis chronica atrophicans (ACA), a late-stage manifestation of Lyme borreliosis; despite a marked T-cell infiltrate in lesional skin and high antibody titres in patients' sera. OBJECTIVES: To determine whether antigen-presenting Langerhans cells (LCs), which reportedly show signs of injury in erythema chronicum migrans (ECM), the early stage of disease, are altered in ACA. PATIENTS/METHODS: We studied the immunophenotype of cutaneous leucocytes on cryostat sections of lesional skin from both ECM and ACA patients. RESULTS: The total number of CD1a+ cells evaluated by semiautomatic image analysis was lower in ECM (594 +/- 263 cells mm(-2) epidermis) than in ACA (835 +/- 317 cells mm(-2) epidermis). HLA-DR expression was remarkably downregulated on CD1a+ LCs to 29% in ECM and 18% in ACA, whereas in normal skin, most of the epidermal CD1a+ dendritic cells were HLA-DR+. The inflammatory infiltrate was mainly composed of CD68+ macrophages and CD45RO+ memory T cells, with a predominance of CD4+ helper T cells. CONCLUSIONS: It is conceivable that the downregulation of major histocompatibility complex class II molecules on LC in both the early and late skin manifestations of Lyme borreliosis is indicative of a poorly effective anti-B. burgdorferi immune response and thus at least partly responsible for the insufficient elimination of this micro-organism from ACA skin.
- Find related publications in this database (using NLM MeSH Indexing)
- Acrodermatitis - immunology
- Adult - immunology
- Aged - immunology
- Aged, 80 and over - immunology
- Antigens, CD1 - metabolism
- Chronic Disease - metabolism
- Down-Regulation - metabolism
- Epidermis - immunology
- Female - immunology
- Fluorescent Antibody Technique - immunology
- HLA-DR Antigens - metabolism
- Humans - metabolism
- Immunoenzyme Techniques - metabolism
- Immunophenotyping - metabolism
- Langerhans Cells - immunology
- Lyme Disease - immunology
- Male - immunology
- Middle Aged - immunology
- Find related publications in this database (Keywords)
- acrodermatitis chronica atrophicans
- antigen presentation
- Borrelia burgdorferi
- chronic Lyme borreliosis
- Langerhans' cells
- major histocompatibility complex class (MHC) II molecules