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Selected Publication:
Leitner, G; Westmoreland, D; Knapp, M; Spencer, K; Merback, J; Kuzik, V; Weger, M; Pfannhauser, W; Porta, S.
Stress induced electrolyte and blood gas changes with and without a six days oral treatment with elderberry (Sambucus Nigra L.) concentrate
MAGNESIUM-BULL 2000 22: 72-76.
Web of Science
- Leading authors Med Uni Graz
- Leitner Gerhard
- Porta Sepp
- Co-authors Med Uni Graz
- Weger Martin
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- Abstract:
- Elderberry juice has a very high content of phenolic compounds. These phenolic constituents of the elderberry have been the focus of attention in recent studies. By a very delicate process the constituents of the elderberry can be concentrated. In the liquid product the anthocyanins are concentrated eleven- and nine-fold respectively containing 130 000 mg/l of anthocyanines and 30 000 mg/l of catechins. The capsule formula (400 mg dry powder per capsule) contains 140 mg of anthocyanins and 34 mp of catechins each.We investigated the impact of a daily intake of 7 000 mg of anthocyanins and 1 700 mg of catechins on 15 human probands. Their reaction to a standardized bicycle ergometry before and after six days of elderberry concentrate treatment was tested by determination of blood gases, ionized electrolytes, lactate and blood glucose.Basal values before ergometric workload showed significant differences after the elderberry concentrate treatment: pH from 7,372 to 7,428 (p = 0.00003), pCO(2) from 40,2 to 33,2 (p = 0.000006), HCO3 from 22,74 to 21,24 (p = 0.0014), pO(2) from 79 to 65 mmHg (p = 0.0004), O-2 saturation from 94.8 to 92,7 (p = 0.01). Lactate. blood sugar, calcium and sodium were not significantly different before and after elderberry treatment. However, ionized magnesium was significantly lower after treatment (iMg from 0,54 to 0,46 mmol/L, p = 0.0001).The impact of the standardized ergometric workload before and after treatment also resulted in various alterations of the parameters measured: after elderberry treatment O2 sat significantly increased after ergometry (p = 0,002), magnesium and blood glucose significantly decreased (p = 0.0004 and p = 0,04, resp.). Lactate delta values were significantly increased after treatment (D = 0,04). Treatment with elderberry concentrate seems to lead to a considerable increase of metabolism, shown by decreased basal values of pCO(2), increased pH and - interestingly - at the same time decreased pO(2) accompanied by decreased magnesium levels. Thus, tissue seems to take up more oxygen (n spite of increased pH) due to and resulting in increased breathing frequency. This and a more pronounced blood glucose and lactate alteration after ergometry along with a drastic fall in ionized serum magnesium are indicators of a boosted metabolism.We suggest that treatment with anthocyanines and polphenoles is increasing metabolic turnover leading to a magnesium deficient status in the long run. In further investigations the feasibility of an accompanying magnesium substitution to stabilize metabolic effects should be undertaken.