Medizinische Universität Graz - Research portal
Selected Publication:
Muellegger, RR; Hofer, A; Salmhofer, W; Soyer, HP; Kerl, H; Wolf, P.
Extended extracorporeal photochemotherapy with extracorporeal administration of 8-methoxypsoralen in systemic sclerosis. An Austrian single-center study.
Photodermatol Photoimmunol Photomed. 2000; 16(5):216-223
Doi: 10.1034/j.1600-0781.2000.160505.x
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- Leading authors Med Uni Graz
- Muellegger Robert
- Co-authors Med Uni Graz
- Hofer Angelika
- Kerl Helmut
- Salmhofer Wolfgang
- Soyer Hans Peter
- Wolf Peter
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- Abstract:
- BACKGROUND: Extracorporeal photochemotherapy (EXP) is an immunomodulating therapy that has been used in a limited number of patients with systemic sclerosis (SSC) with controversial results. The present study was performed to evaluate the efficacy and safety of extended EXP with extracorporeal application of liquid 8-methoxypsoralen (8-MOP) in the treatment of SSC. METHODS: Eleven women with progressive SSC of recent onset were treated for a period of 16-57 months. Skin changes, physical performance, extracutaneous manifestations, and quality of life were evaluated before initiation of EXP and at regular intervals thereafter. RESULTS: From the start to the last set of EXP, we observed an overall improvement and/or stabilization of skin changes and physical performance in 5 of 11 patients (45%). Extracutaneous manifestations deteriorated in 10 of 11 patients (91%) (P<0.05), and quality of life deteriorated in 9 of 11 patients (82%) from a mean score of 10 before, to 17 at the last set of EXP (P<0.05). No major side effects were noted. CONCLUSION: Extended EXP with extracorporeal administration of 8-MOP is a safe and well tolerated treatment modality. However, it provides only (minor) improvement of skin changes of a subset of SSC patients and does not beneficially influence extracutaneous manifestations and quality of life.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Austria -
- Combined Modality Therapy -
- Female -
- Humans -
- Methoxsalen - administration and dosage
- Middle Aged - administration and dosage
- Photochemotherapy - methods
- Photosensitizing Agents - administration and dosage
- Quality of Life - administration and dosage
- Scleroderma, Systemic - drug therapy
- Statistics, Nonparametric - drug therapy
- Treatment Outcome - drug therapy
- Ultraviolet Therapy - drug therapy
- Find related publications in this database (Keywords)
- systemic sclerosis
- extracorporeal photochemotherapy
- parenteral 8-methoxypsoralen