Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Kollroser, M; Henning, G; Gatternig, R; Schober, C.
HPLC-ESI-MS/MS determination of zuclopenthixol in a fatal intoxication during psychiatric therapy.
Forensic Sci Int. 2001; 123(2-3):243-247
Doi: 10.1016/S0379-0738(01)00540-0
(- Case Report)
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- Führende Autor*innen der Med Uni Graz
- Kollroser Manfred
- Co-Autor*innen der Med Uni Graz
- Gatternig Regina
- Henning Gerald
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- Abstract:
- The first non-suicidal fatality due to intramuscular administration of Cisordinol (zuclopenthixol, ZPT) is described. A new, rapid, and sensitive method for the determination of ZPT in postmortem specimens has been developed. High performance liquid chromatography electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS) was employed for drug confirmation and quantitation. Sample clean up was performed using a simple liquid-liquid extraction procedure. The postmortem concentration of ZPT in heart blood was 0.68 microg/ml. Furthermore, zotepine, carbamazepine, and chlorprotixene were detected in body fluids. The proposed method enables the unambiguous identification and quantitation of ZPT and other neuroleptic drugs in clinical and forensic specimens.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Antipsychotic Agents - administration and dosage
- Bipolar Disorder - drug therapy
- Chromatography, High Pressure Liquid - drug therapy
- Clopenthixol - administration and dosage
- Fatal Outcome - administration and dosage
- Female - administration and dosage
- Flupenthixol - blood
- Forensic Medicine - blood
- Humans - blood
- Injections, Intramuscular - blood
- Spectrometry, Mass, Electrospray Ionization - blood
- Find related publications in this database (Keywords)
- zuelopenthixol
- Cisordinol (R)
- neuroleptics
- intoxication
- chromatography