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Selected Publication:
Gallistl, S; Sudi, KM; Aigner, R; Borkenstein, M.
Changes in serum interleukin-6 concentrations in obese children and adolescents during a weight reduction program.
Int J Obes Relat Metab Disord. 2001; 25(11):1640-1643
Doi: 10.1038/sj.ijo.0801808
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- Leading authors Med Uni Graz
- Gallistl Siegfried
- Co-authors Med Uni Graz
- Aigner Reingard
- Borkenstein Helmuth Martin
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- Abstract:
- OBJECTIVE: To investigate the effect of short term energy restriction combined with physical activity on serum concentrations of Interleukin-6 (IL-6) in obese children and adolescents. DESIGN: Longitudinal intervention study of 3.8-5 MJ daily with exercise. SUBJECTS: Forty-nine white obese children and adolescents (31 girls, age 11.9+/-1.8 y; 18 boys, age 11.6+/-1.7 y). MEASUREMENTS: Indexes of obesity, IL-6, leptin, estradiol, systolic and diastolic blood pressure, heart rate at baseline and after 3 weeks. RESULTS: All determined parameters decreased significantly during the 3 week program (IL-6: 3.9+/-4.7 vs 2.0+/-2.2 pg/ml; P<0.05). Body mass index (BMI) fat mass, percentage fat mass (indexes of obesity), and leptin were not related to IL-6 before the program. In contrast, IL-6 concentrations correlated significantly with indexes of obesity and leptin after weight loss. IL-6 concentrations did not correlate with estradiol, systolic and diastolic blood pressure, and heart rate. Changes in IL-6 concentrations correlated significantly with changes in BMI (r=0.25, P<0.05). CONCLUSION: An improved body composition induced by restriction of energy intake and increase in physical activity is associated with more favorable serum concentrations of IL-6 in obese children and adolescents.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Blood Pressure -
- Body Mass Index -
- Child -
- Diet, Reducing -
- Enzyme-Linked Immunosorbent Assay -
- Estradiol - blood
- Exercise - blood
- Female - blood
- Heart Rate - blood
- Humans - blood
- Interleukin-6 - blood
- Leptin - blood
- Male - blood
- Obesity - blood
- Weight Loss - blood
- Find related publications in this database (Keywords)
- interleukin 6
- children
- weight loss