Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Lackner, H; Benesch, M; Schagerl, S; Kerbl, R; Schwinger, W; Urban, C.
Prospective evaluation of late effects after childhood cancer therapy with a follow-up over 9 years.
Eur J Pediatr. 2000; 159(10):750-758
Doi: 10.1007/PL00008340
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- Führende Autor*innen der Med Uni Graz
- Lackner Herwig
- Co-Autor*innen der Med Uni Graz
- Benesch Martin
- Kerbl Reinhold
- Schwinger Wolfgang
- Urban Ernst-Christian
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- Abstract:
- Intensive multimodality treatment has led to a remarkable improvement of prognosis in paediatric cancer patients, however, a great number of long-term survivors suffer from considerable tumour- or treatment-related late effects. Between January 1990 and December 1998, 223 consecutive survivors of childhood malignancies entered a prospective follow-up study designed to evaluate the frequency and severity of tumour- and/or therapy-related long-term sequelae. After cessation of therapy and subsequently once a year, all patients underwent a detailed examination programme including physical examination, laboratory tests, abdominal sonography, echocardiography, electrocardiography, electroencephalography, spirometry, audiometry, ophthalmological examination and endocrine stimulation tests. Median follow-up was 5 years (range 0.4 to 9.6 years). A total of 167 patients (75%) had at least one chronic medical problem of whom 80 needed permanent medical support. The organ systems most frequently affected were the nervous system in 39%, the endocrine system in 32%, the ears/eyes in 22%, the kidneys in 17%, and the liver in 12% of the patients. Some late effects (endocrine deficits, hearing loss, tubulopathy) were primarily diagnosed only several years after the end of oncological therapy. CONCLUSION: The results of this study indicate that a considerable number of former paediatric cancer patients suffer from remarkable long-term side-effects. Since life quality is an important parameter of cancer survival, careful follow-up of long-term survivors is mandatory with the aim to reduce or even abrogate possible side-effects at the earliest time.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Austria - epidemiology
- Child - epidemiology
- Chronic Disease - epidemiology
- Combined Modality Therapy - epidemiology
- Female - epidemiology
- Follow-Up Studies - epidemiology
- Humans - epidemiology
- Infant - epidemiology
- Male - epidemiology
- Neoplasms - psychology
- Outcome Assessment (Health Care) - psychology
- Prospective Studies - psychology
- Quality of Life - psychology
- Rehabilitation - methods
- Severity of Illness Index - methods
- Surgical Procedures, Operative - statistics and numerical data
- Survivors - psychology
- Find related publications in this database (Keywords)
- long-term late effects
- childhood
- cancer
- therapy
- follow-up examinations