Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Gratze, G; Fortin, J; Labugger, R; Binder, A; Kotanko, P; Timmermann, B; Luft, FC; Hoehe, MR; Skrabal, F.
beta-2 Adrenergic receptor variants affect resting blood pressure and agonist-induced vasodilation in young adult Caucasians.
Hypertension. 1999; 33(6):1425-1430
Doi: 10.1161/01.HYP.33.6.1425
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- Co-Autor*innen der Med Uni Graz
- Binder Alexander
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- Abstract:
- Recent evidence suggests that the prodownregulatory Gly16 allele of the beta-2 adrenergic receptor (beta-2 AR) is associated with essential hypertension in African Caribbeans. To further investigate the effect of the glycine (Gly)16 and arginine (Arg)16 beta-2 AR variants on hemodynamics, we investigated the agonist-mediated in vivo vasodilation in normotensive Austrian Caucasians and analyzed the results with respect to the Gly16/Arg16 polymorphism. Fifty-seven normotensive men, 20 to 32 years of age with body mass index of 18.7 to 29.9 kg/m2, were genotyped for the Arg16/Gly16 beta-2 AR alleles. All 15 Gly16/Gly16 subjects, all 12 Arg16/Arg/16 subjects, and 27 of 30 heterozygous subjects underwent hemodynamic measurements while supine after an overnight fast. The observers were unaware of the subjects' genotypes. The subjects received a graded infusion of the selective beta-2 AR agonist salbutamol (0.07, 0.14, and 0.21 microgram/kg per minute, respectively), each dose over 8 minutes. Stroke volume and blood pressure were determined continuously by means of impedance cardiography and oscillometry, respectively. The last 4 minutes of each infusion were evaluated statistically. Basal mean blood pressure was higher in the Gly16/Gly16 subjects compared with Arg16/Arg16 subjects (mean+/-SD: 81.6+/-6.14 versus 75.2+/-4.93 mm Hg, P<0.01). Homozygous Gly16 subjects showed a significantly decreased vasodilation during the first dose of salbutamol infusion compared with Arg16/Arg16 subjects (Deltatotal peripheral resistance index -17.9+/-14.4 versus -30. 6+/-8.3%, P<0.01) despite increased sympathetic counterregulation in the Arg16/Arg16 group (Deltaheart rate +16.9+/-7.0% versus +8.6+/-7. 0%, P<0.01; Deltacardiac index +39.5+/-18.5% versus 21.4+/-18.8%, P<0.05). Our results provide additional evidence that the Gly16/Arg16 alleles of the beta-2 AR are intimately related to blood pressure regulation and deserve further studies in the pathogenesis of essential hypertension.
- Find related publications in this database (using NLM MeSH Indexing)
- Adrenergic beta-Agonists - administration and dosage
- Adult - administration and dosage
- Albuterol - administration and dosage
- Alleles - administration and dosage
- Arginine - administration and dosage
- Austria - administration and dosage
- Blood Pressure - drug effects
- Body Mass Index - drug effects
- European Continental Ancestry Group - genetics
- Genotype - genetics
- Glycine - genetics
- Hemodynamic Processes - drug effects
- Heterozygote - drug effects
- Humans - drug effects
- Infusions, Intravenous - drug effects
- Male - drug effects
- Polymorphism, Genetic - drug effects
- Receptors, Adrenergic, beta-2 - genetics
- Stroke Volume - drug effects
- Supine Position - drug effects
- Variation (Genetics) - drug effects
- Vasodilation - drug effects
- Find related publications in this database (Keywords)
- Hypertension
- Essential
- Molecular Genetics
- Beta-2 Adrenergic Receptor
- Arg16/Gly16 Allele
- Vasodilation
- Impedance Cardiography