Medizinische Universität Graz - Research portal
Selected Publication:
Leis, HJ; Köfeler, H; Raspotnig, G; Zach, D; Fauler, G; Windischhofer, W.
Effect of the aminosteroid U73122 on prostaglandin E(2) production in a murine clonal osteoblast-like cell line, MC3T3-E1.
Biochem Pharmacol. 2000; 60(7):899-904
Doi: 10.1016%2FS0006-2952%2800%2900401-9
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- Leading authors Med Uni Graz
- Leis Hans-Joerg
- Co-authors Med Uni Graz
- Fauler Günter
- Köfeler Harald
- Windischhofer Werner
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- Abstract:
- Prostaglandin E(2) production stimulated by various agents (arachidonic acid, prostaglandin F(2alpha), ionomycin, the calcium ionophore A23187, and melittin) was investigated after pretreatment of murine osteoblast-like MC3T3-E1 cells with the putative phospholipase C blocker, U73122. The aminosteroid dose dependently inhibited prostaglandin E(2) production induced by all agonists, except arachidonic acid. The results suggest an inhibitory role of U73122 on phospholipase A(2) activity or activation.
- Find related publications in this database (using NLM MeSH Indexing)
- Abortifacient Agents - pharmacology
- Animals - pharmacology
- Anti-Bacterial Agents - pharmacology
- Arachidonic Acid - metabolism
- Calcimycin - pharmacology
- Calcium - metabolism
- Carbon Radioisotopes - metabolism
- Cell Line - metabolism
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- Dinoprost - pharmacology
- Dinoprostone - biosynthesis
- Enzyme Activation - biosynthesis
- Estrenes - pharmacology
- Ionomycin - pharmacology
- Melitten - pharmacology
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- Find related publications in this database (Keywords)
- U73122
- phospholipase C
- osteoblast