Medizinische Universität Graz - Research portal
Selected Publication:
Mangge, H; Liebmann, P; Tanil, H; Herrmann, J; Wagner, C; Gallistl, S; Schauenstein, K; Erwa, W.
Cystatin C, an early indicator for incipient renal disease in rheumatoid arthritis.
Clin Chim Acta. 2000; 300(1-2):195-202
Doi: 10.1016/S0009-8981(00)00322-3
Web of Science
PubMed
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- Leading authors Med Uni Graz
- Mangge Harald
- Co-authors Med Uni Graz
- Erwa Wolfgang
- Gallistl Siegfried
- Liebmann-Holzmann Peter
- Schauenstein Konrad
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- Abstract:
- Rheumatoid arthritis (RA) is a chronic disease requiring potential nephrotoxic therapy with nonsteroidal antiinflammatory drugs (NSAIDs) and disease modifying antirheumatic drugs (DMARDs). The rationale of our study was to examine the renal status of patients suffering from prolonged RA by means of plasma cystatin C, a new parameter of renal function. Fifty-six patients affected with RA for more than 5 years, and treated with NSAIDs for more than 50 months, were included in the study. Besides conventional markers of renal function (i.e. plasma creatinine, estimated glomerular filtration rate, creatinine clearance), we analysed plasma cystatin C by an automated, nephelometric immunoassay on a Behring nephelometer. Sixty percent of the RA patients exhibited elevated levels of plasma cystatin C, whereas only three out of 56 patients showed an elevated plasma creatinine, even though the creatinine clearance was decreased in 57% of these patients. Cystatin C exhibited a by far better correlation with creatinine clearance than plasma creatinine. In conclusion, patients with prolonged RA for more than 50 months, show a disturbed renal function despite normal plasma creatinine. Elevated cystatin C indicates such incipient renal disease, and is, not least because of a simple, well reproducible technique, more recommendable for screening purposes than tedious clearance determinations.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Arthritis, Rheumatoid - blood Arthritis, Rheumatoid - complications
- Biomarkers - blood
- Cystatin C -
- Cystatins - blood
- Female -
- Humans -
- Kidney Diseases - blood Kidney Diseases - complications Kidney Diseases - diagnosis
- Male -
- Middle Aged -
- Find related publications in this database (Keywords)
- prolonged RA
- early renal damage
- diagnosis
- cystatin C