Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Wagner, T; Berer, A; Lanzer, G; Geissler, K.
Kell is not restricted to the erythropoietic lineage but is also expressed on myeloid progenitor cells.
Br J Haematol. 2000; 110(2):409-411
Doi: 10.1046%2Fj.1365-2141.2000.02195.x
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Wagner Thomas
- Co-Autor*innen der Med Uni Graz
- Lanzer Gerhard
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Anti-Kell antibodies have been shown to suppress fetal erythropoiesis, but little is known about their effect on myelopoiesis. We analysed the effect of Kell-related antibodies on granulocyte-macrophage colony-forming units (CFU-GM) growth in semisolid medium using peripheral blood mononuclear cells (PBMNCs) from haematologically normal individuals. In addition to its inhibitory effect on erythroid burst-forming units (BFU-E) growth, anti-Kell antibodies significantly reduced CFU-GM colony formation from Kell-positive individuals but not from Kell-negative donors. Moreover, anti-cellano and anti-Kpb antibodies also inhibited the growth of CFU-GM from antigen-positive MNCs. These data indicate that Kell is not restricted to erythroid blood cells, but is also expressed on myeloid progenitor cells.
- Find related publications in this database (using NLM MeSH Indexing)
- Antibodies -
- Cells, Cultured -
- Erythropoiesis - immunology
- Granulocytes - physiology
- Hematopoietic Stem Cells - immunology
- Humans - immunology
- Kell Blood-Group System - immunology
- Leukocytes, Mononuclear - physiology
- Leukopoiesis - immunology
- Macrophages - physiology
- Find related publications in this database (Keywords)
- Kell
- CFU-GM
- BFU-E
- haematopoiesis
- human blood groups