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Giuliani, A; Concin, H; Wieser, F; Boritsch, J; Wilfert, H; Gruber, D; Urdl, W.
Hormone replacement therapy with a transdermal estradiol gel and oral micronized progesterone. Effect on menopausal symptoms and lipid metabolism
Wien Klin Wochenschr. 2000; 112(14):629-633
Web of Science PubMed

Leading authors Med Uni Graz: Giuliani Albrecht
Co-authors Med Uni Graz: Urdl Wolfgang
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Abstract:: In a multicenter observational study, the efficacy and acceptance of two different regimens of postmenopausal hormone replacement therapy in the form of a combination of 17 beta-estradiol in percutaneous gel application and micronized oral progesterone were evaluated. Forty-eight patients (aged 40-66 years) received 2.5 g estradiol gel plus either continuously micronized progesterone 100 per day (group A) or, sequentially, 200 mg per day between day 16 and 25 of a monthly cycle (group B) for two months. A significant reduction in typical menopausal symptoms, especially vasomotor complaints like hot flushes or sweating, was observed in both groups (score average at the beginning for hot flushes: 2.0 in group A and 1.8 in group B; after two months of treatment, 0.7 in group A and 0.4 in group B). Cholesterol levels were slightly reduced but statistically significant (235.9 +/- 49.55 mg/dl vs. 226.3 +/- 52.24 mg/dl; p < 0.05) only in group A; a trend towards lower cholesterol was observed in group B (236.5 +/- 47.82 mg/dl vs. 227.4 +/- 44.72 mg/dl). Lipoprotein (a) was also significantly reduced in group A (32.57 +/- 36.52 mg/dl vs. 28.28 +/- 31.03 mg/dl in group A; 31.7 +/- 28.42 mg/dl vs. 28.34 +/- 23.71 in group B; p < 0.05). The overall acceptance of this therapy was excellent or good in 91.3% of group A and 92.8% of group B patients.
Find related publications in this database (using NLM MeSH Indexing): Administration, Cutaneous -; Administration, Oral -; Adult -; Aged -; Cholesterol - blood; Drug Carriers - blood; Estradiol - administration and dosage; Estrogen Replacement Therapy - methods; Female - methods; Humans - methods; Lipids - blood; Lipoprotein(a) - blood; Liposomes - blood; Menopause - drug effects; Middle Aged - drug effects; Patient Satisfaction - drug effects; Progesterone - administration and dosage; Time Factors - administration and dosage; Treatment Outcome - administration and dosage; Triglycerides - blood
Find related publications in this database (Keywords): hormone replacement therapy; 17 beta-estradiol; progesterone; total cholesterol; lipoprotein (a)