Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Schwinger, W; Urban, C; Lackner, H; Kerbl, R; Benesch, M; Dornbusch, HJ; Sovinz, P; Schumm, M; Handgretinger, R.
Unrelated partially matched peripheral blood stem cell transplantation with highly purified CD34+ cells in a child with Wiskott-Aldrich syndrome.
Bone Marrow Transplant. 2000; 26(2):235-237
Doi: 10.1038/sj.bmt.1702473
(- Case Report)
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- Führende Autor*innen der Med Uni Graz
- Schwinger Wolfgang
- Co-Autor*innen der Med Uni Graz
- Benesch Martin
- Dornbusch Hans Jürgen
- Kerbl Reinhold
- Lackner Herwig
- Ritter-Sovinz Petra
- Urban Ernst-Christian
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- Abstract:
- Stem cell transplantation is the only curative approach to the treatment of Wiskott-Aldrich syndrome. However, using grafts from partially matched unrelated donors is associated with increased risk of graft rejection and graft-versus-host disease. In an attempt to prevent these problems, a 6-year-old boy with Wiskott-Aldrich syndrome lacking a suitable family donor, was transplanted with large numbers of unrelated highly purified CD34+ peripheral blood stem cells mismatched at one C locus. Conditioning consisted of busulfan 16 mg/kg body weight, cyclophosphamide 200 mg/kg body weight and antithymocyte globulin 20 mg/kg body weight x 3 days. The boy had a rapid hematopoietic engraftment and showed immunologic reconstitution by day +92. Although he did not receive prophylactic immunosuppression he did not develop any graft-versus-host disease and is well and alive up to now, 25 months after transplantation.
- Find related publications in this database (using NLM MeSH Indexing)
- Antigens, CD34 - analysis
- Graft Survival - analysis
- Hematopoietic Stem Cell Transplantation - methods
- Histocompatibility - immunology
- Humans - immunology
- Infant - immunology
- Leukapheresis - immunology
- Male - immunology
- Stem Cells - immunology
- Transplantation, Homologous - methods
- Wiskott-Aldrich Syndrome - immunology
- Find related publications in this database (Keywords)
- Wiskott-Aldrich syndrome
- peripheral blood stem cell transplantation
- MACS
- CD34-selection