Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Cerroni, L; Soyer, HP; Kerl, H.
bcl-2 protein expression in cutaneous malignant melanoma and benign melanocytic nevi.
Am J Dermatopathol. 1995; 17(1):7-11
Doi: 10.1097/00000372-199502000-00002
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- Führende Autor*innen der Med Uni Graz
- Cerroni Lorenzo
- Co-Autor*innen der Med Uni Graz
- Kerl Helmut
- Soyer Hans Peter
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- Abstract:
- bcl-2 is a proto-oncogene belonging to a new category of oncogenes that are not involved in the mechanisms of cell proliferation but instead influence tissue homeostasis regulating cell death. The gene encodes for a protein that preserves cells from death by apoptosis, allowing them to survive in G(o) phase even in the absence of essential growth factors. The expression of bcl-2 protein has been observed in most follicular lymphomas and in approximately 25% of high-grade non-Hodgkin's lymphomas, as well as in solid tumors such as carcinomas of the lung, prostate, and nasopharynx. In this study, we analyzed bcl-2 protein expression in cutaneous malignant melanoma (MM) (29 cases) and benign melanocytic nevi (BMN) (35 cases) using a high specific anti-bcl-2 monoclonal antibody with a standard three-step immunoperoxidase technique on formalin-fixed, paraffin-embedded tissue sections. High levels of bcl-2 protein were observed in 27 of 29 MM (93.1%) and 33 of 35 BMN (94.3%). Our results indicate that bcl-2 protein expression is a common finding in cutaneous melanocytic lesions regardless of their biologic behavior. Expression of the protein in the great majority of MM seems to exclude a prognostic significance of bcl-2 in MM of the skin.
- Find related publications in this database (using NLM MeSH Indexing)
- Antibodies, Monoclonal -
- Apoptosis - genetics
- Cell Death - genetics
- Dysplastic Nevus Syndrome - genetics
- G0 Phase - genetics
- GTP-Binding Proteins - genetics
- Gene Expression Regulation, Neoplastic - genetics
- Humans - genetics
- Immunoenzyme Techniques - genetics
- Melanoma - genetics
- Nevus, Blue - genetics
- Nevus, Epithelioid and Spindle Cell - genetics
- Nevus, Pigmented - congenital
- Protein-Tyrosine Kinases - genetics
- Proto-Oncogene Proteins - genetics
- Proto-Oncogene Proteins c-bcl-2 - genetics
- Skin Neoplasms - genetics
- Find related publications in this database (Keywords)
- Melanocytic Lesions
- Oncogenes
- Solid Tumors
- Skin