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Selected Publication:
Kreil, A; Wenisch, C; Brittenham, G; Looareesuwan, S; Peck-Radosavljevic, M.
Thrombopoietin in Plasmodium falciparum malaria.
Br J Haematol. 2000; 109(3):534-536
Doi: 10.1046%2Fj.1365-2141.2000.02096.x
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- Co-authors Med Uni Graz
- Wenisch Christoph
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- Abstract:
- Thrombopoietin (TPO) is the key growth factor for platelet production and is elevated in states of platelet depletion. As thrombocytopenia is a common finding in malaria, we analysed TPO regulation before, during and after antimalarial treatment. Before treatment, TPO serum levels were significantly higher in patients with severe malaria (n = 35) than in patients with uncomplicated malaria (n = 44; P = 0.024), normalizing within 14-21 d of therapy. The rapid normalization of TPO levels and increase in low peripheral platelet counts after treatment indicate that the biosynthesis of TPO and its regulation in malaria patients are normal.
- Find related publications in this database (using NLM MeSH Indexing)
- Antimalarials - therapeutic use
- Artemisinins - therapeutic use
- Humans - therapeutic use
- Kidney Failure, Acute - blood
- Malaria, Cerebral - blood
- Malaria, Falciparum - blood
- Platelet Count - blood
- Sesquiterpenes - therapeutic use
- Statistics, Nonparametric - therapeutic use
- Thrombopoietin - drug effects
- Find related publications in this database (Keywords)
- malaria
- Plasmodium falciparum
- thrombopoietin (TPO)
- peripheral platelet count (PPC)
- disseminated intravascular coagulation (DIC)