Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Fazekas, F; Strasser-Fuchs, S; Schmidt, H; Enzinger, C; Ropele, S; Lechner, A; Flooh, E; Schmidt, R; Hartung, HP.
Apolipoprotein E genotype related differences in brain lesions of multiple sclerosis.
J Neurol Neurosurg Psychiatry. 2000; 69(1):25-28
Doi: 10.1136%2Fjnnp.69.1.25
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- Führende Autor*innen der Med Uni Graz
- Fazekas Franz
- Co-Autor*innen der Med Uni Graz
- Enzinger Christian
- Flooh Erich
- Fuchs Siegrid
- Ropele Stefan
- Schmidt Helena
- Schmidt Reinhold
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- Abstract:
- OBJECTIVES: Clinical reports have speculated on a more severe course of multiple sclerosis in patients with the apolipoprotein E (apoE) epsilon4 allele. As this could be reflected by differences in the severity of tissue damage MRI was used to obtain further support for a disease modifying effect of the apoE genotype. METHODS: Brain MR scans of 83 patients (mean age 35.5 (SD 9.5 years) who participated in a cross sectional study on the distribution of genotype patterns in multiple sclerosis. The total lesion load on proton density weighted (T2-LL) and T1 weighted scans (T1-LL) obtained with conventional spin echo sequences at 1.5 T was measured. A "black hole" ratio ((T1-LL/T2-LL)x100) was also calculated. This indicates the proportion of multiple sclerosis lesions with more severe tissue damage and may reflect disease aggressiveness or quality of repair. RESULTS: Patients with the apoE-epsilon3/epsilon4 genotype (n=19) showed a non-significantly greater T2-LL (16.0 (SD 14.0) cm(3)) than patients with the epsilon2/epsilon3 (n=11; 13.3 (9.5) cm(3)) or the epsilon3/epsilon3 genotype (n=49; 9.4 (SD 9.2) cm(3)). Both the T1-LL (2.6 (SD 3.3) v 1.6 (SD 2.4) and 1.2 (SD 3.0) cm(3); p=0.04) and the black hole ratio (14.3 SD 11.9) v 7.4 (SD 9.3) and 8.4 (SD 13.3)%; p=0.02), however, were significantly higher in epsilon3/epsilon4 patients. Similar differences were seen when comparing patients with at least one epsilon4 allele with the remainder of the group. CONCLUSIONS: These data support speculations on a modulation of multiple sclerosis severity by the apoE genotype which can be attributed to more extensive tissue destruction or less efficient repair in carriers of the epsilon4 allele.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Alleles -
- Apolipoprotein E4 -
- Apolipoproteins E - genetics
- Brain - pathology
- Cross-Sectional Studies - pathology
- Female - pathology
- Genotype - pathology
- Heterozygote Detection - pathology
- Humans - pathology
- Magnetic Resonance Imaging - pathology
- Male - pathology
- Middle Aged - pathology
- Multiple Sclerosis - diagnosis
- Prognosis - diagnosis
- Find related publications in this database (Keywords)
- multiple sclerosis
- apolipoprotein E genotype
- magnetic resonance imaging