Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Weiss, PA; Scholz, HS; Haas, J; Tamussino, KF; Seissler, J; Borkenstein, MH.
Long-term follow-up of infants of mothers with type 1 diabetes: evidence for hereditary and nonhereditary transmission of diabetes and precursors.
Diabetes Care. 2000; 23(7):905-911
Doi: 10.2337/diacare.23.7.905
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- Co-Autor*innen der Med Uni Graz
- Borkenstein Helmuth Martin
- Haas Josef
- Scholz Heinz
- Tamussino Karl
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- Abstract:
- OBJECTIVE: To estimate the impact of type 1 diabetes during pregnancy on transgenerational genetically caused and/or fuel-mediated amplification of types 1 and 2 diabetes and to estimate the impact of elevated amniotic fluid insulin levels. RESEARCH DESIGN AND METHODS: A total of 75 white offspring of type 1 diabetic mothers and 49 control subjects of similar age and pubertal stage were examined at 5-15 years of age. All offspring had an oral glucose tolerance test. Glucose, insulin, and C-peptide were measured at 0, 30, 60, and 120 min after loading. Lipids and autoimmune antibodies were measured in fasting plasma. RESULTS: Of the 75 offspring, 4 (5.3%) had overt diabetes, and 16 of 71 (22.5%) had autoimmune antibodies. Offspring of diabetic mothers had significantly higher BMI; symmetry indexes; cholesterol, glucose, insulin, and C-peptide levels; and insulin resistance than control subjects. With the exception of cholesterol, these values were significantly elevated in offspring who had elevated amniotic fluid insulin levels (>8 microU/ml, >48 pmol/l) during pregnancy compared with normoinsulinemic offspring and control subjects. CONCLUSIONS: Offspring of type 1 diabetic mothers have an increased risk for diabetes later in life. The relative risk for type 1 and type 2 diabetes is 71.6 and 3.2, respectively. Type 2 diabetes-associated risk factors, such as high BMI; elevated glucose, insulin, and C-peptide levels; and insulin resistance, are related to the fetal metabolic experience in utero, as reflected by amniotic fluid insulin concentration.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Age of Onset -
- Autoantibodies - blood
- Blood Glucose - metabolism
- C-Peptide - blood
- Child -
- Child, Preschool -
- Cholesterol - blood
- Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - epidemiology Diabetes Mellitus, Type 1 - genetics
- European Continental Ancestry Group -
- Female -
- Follow-Up Studies -
- Genomic Imprinting -
- Germany -
- Humans -
- Insulin - blood
- Lipids - blood
- Longitudinal Studies -
- Male -
- Mothers -
- Pregnancy -
- Pregnancy in Diabetics -