Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Comi, G; Kappos, L; Clanet, M; Ebers, G; Fassas, A; Fazekas, F; Filippi, M; Hartung, HP; Hertenstein, B; Karussis, D; Martino, G; Tyndall, A; van der Meché, FG.
Guidelines for autologous blood and marrow stem cell transplantation in multiple sclerosis: a consensus report written on behalf of the European Group for Blood and Marrow Transplantation and the European Charcot Foundation. BMT-MS Study Group.
J Neurol. 2000; 247(5):376-382
Doi: 10.1007%2Fs004150050605
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- Co-Autor*innen der Med Uni Graz
- Fazekas Franz
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- Abstract:
- Recent reports suggest the possible beneficial effects of haemopoietic stem cell transplantation (HSCT) in autoimmune diseases such as multiple sclerosis (MS). The definition of the risk/benefit ratio for such a treatment is perceived as a major issue for the neurological community worldwide. The First Consensus Conference on Bone Marrow Transplantation in Patients with Multiple Sclerosis was held in Milan, Italy on 21 February 1998. Participants from 16 European, North American, and South American countries discussed the guidelines for performing HSCT in MS. This conference was organized in order to: (a) define criteria for patient selection; (b) define transplantation procedures to maximize efficacy of the treatment and minimize its toxicity; (c) standardize patient outcome evaluation; and (d) establish an international working group to evaluate the efficacy and safety of HSCT in MS and to study the immunological changes related to HSCT in MS patients. During the meeting in Milan agreement was reached on: (a) the preparation and distribution of a consensus report on HSCT in MS and (b) the design of an open trial for an initial assessment of the safety and efficacy of HSCT in MS. The consensus reached during the meeting and the design of the clinical trial are summarized in this contribution.
- Find related publications in this database (using NLM MeSH Indexing)
- Blood Transfusion, Autologous -
- Bone Marrow Transplantation -
- Hematopoietic Stem Cell Transplantation -
- Humans -
- Multiple Sclerosis - surgery
- Find related publications in this database (Keywords)
- multiple sclerosis
- haemopoietic stem cell transplantation
- consensus guidelines