Medizinische Universität Graz - Research portal
Selected Publication:
Archelos, JJ; Hartung, HP.
Pathogenetic role of autoantibodies in neurological diseases.
TRENDS NEUROSCI. 2000; 23(7): 317-327.
Doi: 10.1016/S0166-2236(00)01575-7
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- Leading authors Med Uni Graz
- Archelos-Garcia Juan-Jose
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- Abstract:
- Autoreactive B cells and antibodies can be detected in a variety of neurological diseases. Their causative role has been established in some disorders and they are obviously involved in the pathogenesis of others. Some mechanisms engendering B-cell autoimmunity in animal models have been shown to operate in humans. Factors that determine B-cell immune-response patterns and the effector pathways have been identified. B-cell responses to CNS-restricted autoantigens are governed by distinctive immune reactions. Evidence has accumulated that the CNS is a permissive and, under inflammatory conditions, even a B-cell-supporting micro-environment. Data from human and animal experiments have enhanced our understanding of B-cell physiology in health and neurological disease, which has relevant diagnostic and therapeutic implications.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Autoantibodies - immunology
- B-Lymphocytes - immunology
- Central Nervous System - immunology
- Humans - immunology
- Nervous System Diseases - immunology