Medizinische Universität Graz - Research portal
Selected Publication:
Olipitz, W; Beham-Schmid, C; Aigner, R; Raith, J; Linkesch, W; Sill, H.
Acute myelofibrosis: multifocal bone marrow infiltration detected by scintigraphy and magnetic resonance imaging.
ANN HEMATOL 2000 79: 275-278.
Doi: 10.1007%2Fs002770050593
(- Case Report)
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- Leading authors Med Uni Graz
- Olipitz Werner
- Sill Heinz
- Co-authors Med Uni Graz
- Aigner Reingard
- Beham-Schmid Christine
- Linkesch Werner
- Raith Johann
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- Abstract:
- Acute myelofibrosis is a rare, malignant hematological disorder of unknown etiology with an inevitably fatal outcome. Here we present the study of a 63-year-old Caucasian man with acute onset of pancytopenia. Repeated bone marrow biopsies showed dense fibrosis and hypoplastic hematopoiesis raising various differential diagnoses of malignant and nonmalignant conditions. Bone marrow scintigraphy and magnetic resonance imaging (MRI) showed areas suggesting neoplastic infiltration, mainly in both femurs and tibias. Histological examination of a surgical biopsy of the left tibia revealed acute megakaryoblastic leukemia. As the patient refused polychemotherapy, therapy with interferon gamma was initiated but discontinued prematurely because of intolerable side effects. The presented case therefore suggests that the combination of bone marrow scintigraphy and MRI is a valuable diagnostic tool in patients presenting with myelofibrosis of unknown origin.
- Find related publications in this database (using NLM MeSH Indexing)
- Acute Disease -
- Antineoplastic Agents - therapeutic use
- Bone Marrow - pathology
- Humans - pathology
- Interferon Type II - therapeutic use
- Magnetic Resonance Imaging - therapeutic use
- Male - therapeutic use
- Middle Aged - therapeutic use
- Myelofibrosis - diagnosis
- Platelet-Derived Growth Factor - antagonists and inhibitors
- Research Support, Non-U.S. Gov't - antagonists and inhibitors
- Tibia - pathology
- Transforming Growth Factor beta - antagonists and inhibitors
- Find related publications in this database (Keywords)
- acute myelofibrosis
- acute megakaryoblastic leukemia
- scintigraphy
- magnetic resonance imaging
- interferon gamma