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Fazekas, F; Roob, G; Kleinert, R; Schmidt, R.
MRI foci of signal loss: A possible indication of increased risk for intracerebral haemorrhage
KLIN NEUROPHYSIOL. 2000; 31: S29-S32. Doi: 10.1055/s-2008-1060070
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Leading authors Med Uni Graz: Fazekas Franz
Co-authors Med Uni Graz: Kleinert Reinhold; Schmidt Reinhold
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Abstract:: Magnetic resonance imaging (MRI) of the brain using T-2*-weighted sequences detects focal areas of signal loss in about half of patients with primary intracerebral haemorrhage. These lesions were histopathologically confirmed to represent residues of previous, clinically silent microbleeds and are a consequence of various vasculopathies with hypertensive lipofibrohyalinosis as the leading cause. When associated with cerebral amyloid angiopathy foci of signal loss tend to be located primarily at cortico-subcortical sites. Most importantly old microbleeds can also be detected in patients with ischemic vascular diseases and rarely even in the healthy elderly population. Possibly predicting a higher risk for intracerebral hemorrhage in such persons this finding could therefore influence therapeutic decisions regarding the use of agents which increase the likelihood of bleeding. This hypothesis will have to be tested in prospective trials. Already now MRI evidence of microbleeds has some diagnostic relevance for patients with an intracerebral hematoma because of the etiologic implications of this observation.
Find related publications in this database (Keywords): magnetic resonance imaging; intracerebral hemorrhage; microangiopathy; risk for bleeding