Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Sudi, KM; Gallistl, S; Tafeit, E; Möller, R; Borkenstein, MH.
The relationship between different subcutaneous adipose tissue layers, fat mass and leptin in obese children and adolescents.
J Pediatr Endocrinol Metab. 2000; 13(5):505-512
Doi: 10.1515/JPEM.2000.13.5.505
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PubMed
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- Co-Autor*innen der Med Uni Graz
- Borkenstein Helmuth Martin
- Gallistl Siegfried
- Möller Reinhard
- Tafeit Erwin
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- Abstract:
- We studied the relationships of subcutaneous adipose tissue layers (SAT-layers), body fat mass (FM) and waist-to-hip ratio (WHR) with leptin in obese children and adolescents. Twenty-nine obese children and adolescents (12 boys: age: 11.3 +/- 3.7 yr; body mass index [BMI]: 28.5 +/- 4) and 17 girls (age: 12.2 +/- 2.2 yr; BMI: 29.8 +/- 4.7) (mean +/- SD) were studied. FM was estimated by bioelectrical impedance. SAT-layers were determined at 15 different body sites from 1-neck to 15-calf by the Lipometer optical device. Leptin and insulin were determined by RIA. Maturity was associated with a greater thickness of certain SAT-layers from the upper body and with a lower thickness of SAT-layers from the abdominal region and lower extremities. Significant correlations were found for all estimates of adiposity and leptin (all p<0.001). Waist and hip circumferences were not correlated to leptin after adjustment for FM. SAT-layers from the upper body were significantly and positively correlated to leptin. Multiple regression analysis revealed FM as a main contributor to the variation in leptin (R2=0.53, p<0.0001). FM together with SAT-layers 5-front chest and 13-rear thigh explained 72% of the variation in leptin (p<0.0001). In a body fat distribution model, hip circumference together with SAT-layers 4-upper back and 2-triceps explained 75% of the variation in leptin (p< 0.0001). The results suggest that SAT-layers and their topography are main determinants for leptin in obese children and adolescents. Maturity in obese children is associated with higher values of upper body SAT-layers and lower values of abdominal and lower extremities SAT-layers. Whether leptin is under the control of certain subcutaneous adipose tissue depots from the upper body remains to be elucidated by longitudinal studies.
- Find related publications in this database (using NLM MeSH Indexing)
- Adipose Tissue - anatomy and histology
- Adolescent - anatomy and histology
- Body Composition - anatomy and histology
- Body Constitution - anatomy and histology
- Body Mass Index - anatomy and histology
- Child - anatomy and histology
- Female - anatomy and histology
- Humans - anatomy and histology
- Leptin - analysis
- Male - analysis
- Obesity - metabolism
- Regression Analysis - metabolism
- Find related publications in this database (Keywords)
- subcutaneous adipose tissue layers
- leptin
- obesity
- children
- adolescents
- Lipometer