Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Domanovits, H; Schillinger, M; Lercher, P; Stark, T; Stix, G; Sterz, F; Mayrleitner, M; Laggner, AN.
E 047/1: a new class III antiarrhythmic agent.
J Cardiovasc Pharmacol. 2000; 35(5):716-722
Doi: 10.1097/00005344-200005000-00006
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- Co-Autor*innen der Med Uni Graz
- Lercher Peter
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- Abstract:
- The efficacy, pharmacokinetics, safety, and tolerability of E 047/1, an amiodarone derivative, were evaluated in patients with acute supraventricular or ventricular arrhythmia. In an open, nonrandomized prospective multicenter trial, 20 patients were treated with three different i.v. dosage regimens of E 047/1. Arrhythmia termination indicated efficacy. Pharmacokinetics were determined by measurements of drug plasma levels. Safety was judged by changes of blood pressure, heart rate, ECG parameters, and appearance of adverse events. For local tolerability, effects at the site of infusion were assessed. In patients with atrial fibrillation and/or atrial flutter, drug plasma levels and prolongation of QT interval were correlated with efficacy. In 10 (50%) patients, therapeutic intervention with E 047/1 was successful. Drug plasma levels rapidly decreased within 1 h after administration. Blood pressure values and ECG parameters stayed constant during the observation period. Proarrhythmic effects were not observed. As adverse events, vertigo, vomiting, and nausea in three (15%) and hypotension in one (5%) patient, respectively, occurred in the high-dose bolus regimen only. At the site of infusion, no adverse effects were found. No dependency between drug plasma levels and arrhythmia termination was found. E 047/1 has proven to be efficient and safe in the treatment of arrhythmia. E 047/1 is characterized by rapid plasma elimination, absence of proarrhythmic or cardiodepressive effects, mild adverse events, and excellent local tolerability. For further investigation, we recommend a combined bolus- and weight-adapted infusion regimen.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Anti-Arrhythmia Agents - adverse effects
- Arrhythmia - drug therapy
- Benzofurans - adverse effects
- Female - adverse effects
- Hemodynamic Processes - drug effects
- Humans - drug effects
- Male - drug effects
- Middle Aged - drug effects
- Prospective Studies - drug effects
- Find related publications in this database (Keywords)
- E 047/1
- arrhythmia
- efficacy
- safety
- plasma levels
- adverse events