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Krachler, M; Lindschinger, M; Watzinger, N; Eber, B; Wallner, S.
Impact of mechanical vascular injury on whole blood and plasma concentrations of trace elements and electrolytes in patients with coronary heart disease
J TRACE ELEM EXP MED 2000 13: 185-194. Doi: 10.1002/(SICI)1520-670X(2000)13:2<185::AID-JTRA1>3.0.CO;2-F
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Leading authors Med Uni Graz: Holasek Sandra Johanna
Co-authors Med Uni Graz: Watzinger Norbert
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Abstract:: Concentrations of the seven trace elements-cobalt (Co), cesium (Cs), copper (Cu), lead (Pb), rubidium (Rb), strontium (Sr), and zinc (Zn)-were determined in 76 whole blood and 76 plasma samples of patients with coronary heart disease undergoing percutaneous transluminal coronary angioplasty (PTCA) by inductively coupled plasma mass spectrometry. Additionally. concentrations of iron (Fe) and the electrolytes sodium (Na), potassium (K), magnesium (Mg), and calcium (Ca) in the plasma of these patients were determined. To investigate the impact of PTCA on the concentrations of these elements, blood and plasma samples were collected 4-12 hours prior to (n = 16) and 24-30 hours after(n = 60) the clinical intervention. Concentrations for Rb and Cs in whole blood and plasma decreased after PTCA, but remained within the normal ranges reported for healthy adults. Concentrations of Co in whole blood and plasma were higher than the reported reference ranges and decreased significantly (P < 0.0001) in the plasma after the clinical intervention. Plasma Fe prior to PTCA was in the middle of the reference range and decreased significantly (P < 0.001) after PTCA to the very low end of the normal range. All blood Cu concentrations were at the lower end of the normal range and did not change during the clinical intervention. Concentrations of all other elements in the plasma and whole blood of our patients were within the normal ranges for healthy adults and remained unchanged. J. Trace Elem. Exp. Med. 13:185-194, 2000. (C) 2000 Wiley-Liss, Inc.
Find related publications in this database (Keywords): trace elements; blood plasma; coronary heart disease; percutaneous transluminal coronary angioplasty; inductively coupled plasma mass spectrometry