Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Sattler, W; Leblhuber, F; Walli, J; Widner, B; Fuchs, D.
Cerebrospinal fluid levels of alpha-tocopherol and neopterin in patients with dementia
PTERIDINES 1999 10: 220-224.
Doi: 10.1515/pteridines.1999.10.4.220
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- Führende Autor*innen der Med Uni Graz
- Sattler Wolfgang
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- Abstract:
- In patients with different forms of dementia we compared serum and cerebrospinal fluid concentrations of a-tocopherol (vitamin-E), the major circulating lipid-soluble antioxidant, and neopterin, a product released from monocytic cells upon stimulation with interferon-gamma. A significant inverse correlation was found between the concentrations of both compounds in the cerebrospinal fluid. The data point to a role of oxidative stress to reduce antioxidant levels in elderly demented patients with neurodegenerative diseases.
- Find related publications in this database (Keywords)
- alpha-tocopherol
- neopterin
- dementia
- oxidative stress
- Alzheimer type dementia