Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Smolle, J; Hofmann-Wellenhof, R.
Autocrine growth stimulation as a potential source of asymmetry in melanocytic skin tumors.
Am J Dermatopathol. 1998; 20(4):352-356
Doi: 10.1097%2F00000372-199808000-00005
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- Führende Autor*innen der Med Uni Graz
- Smolle Josef
- Co-Autor*innen der Med Uni Graz
- Hofmann-Wellenhof Rainer
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- Abstract:
- The presence of asymmetry is a major diagnostic criterion for the differentiation of melanoma from benign melanocytic proliferations. It is helpful in both clinical and histological evaluation. The underlying biological features that determine asymmetry have not yet been evaluated. Using computer simulation of the growth of neoplasms, we demonstrate that a functionally homogeneous cell population can give rise to asymmetric lesions when the cells respond to autocrine growth signals. In contrast, neoplastic cells that depend on paracrine stimuli tend to form symmetric lesions. Since the progression of melanocytic neoplasms has been demonstrated to be accompanied by increasing independence of paracrine growth signals and the development of autocrine loops, autocrine growth stimulation has to be considered as a potential source of asymmetry in melanoma.
- Find related publications in this database (using NLM MeSH Indexing)
- Autocrine Communication - physiology
- Cell Division - physiology
- Computer Simulation - physiology
- Humans - physiology
- Melanocytes - cytology
- Melanoma - pathology
- Skin Neoplasms - pathology
- Statistics - pathology
- Find related publications in this database (Keywords)
- Asymmetry
- Pattern Analysis
- Melanoma
- Computer Simulation
- Cellular Automaton
- Autocrine Growth Factors