Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Vrecko, K; Walzl, M; Tafeit, E; Reibnegger, G.
Relationship among serum and urine neopterin, fibrinogen, and other serum analytes in atherosclerotic patients and the long-term effect of HELP therapy
PTERIDINES 1999 10: 190-196.
Doi: 10.1515/pteridines.1999.10.4.190
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- Führende Autor*innen der Med Uni Graz
- Vrecko Karoline
- Co-Autor*innen der Med Uni Graz
- Reibnegger Gilbert
- Tafeit Erwin
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- Abstract:
- In 30 atherosclerotic patients different serum analytes and neopterin concentrations in serum and urine were determined before and after Heparin-Induced Extracorporeal LDI, and Fibrinogen Precipitation therapy. Neopterin concentrations in serum of all 30 patients were increased (mean=9.18 nmol/l, SD=3.23) compared to age matched healthy people (mean=5.34 nmol/l, SD=2.70) auld were significantly lowered after H.E.L.P therapy (mean=8.22 nmol/l; SD=3.22, p=0.002, t-test). These results suggest the involvement of the cellular immune system in the occurrence of atherosclerosis. Further neopterin, the macrophage-derived immune activation marker, is significantly correlated with fibrinogen (linear correlation coefficient 0.36, p=0.05). Long-term neopterin concentrations in serum of 4 patients (three with coronary heart disease and one with Papilla edema), from the first up to the 9(th), respectively 12(th) therapy decreased, in contrast to fibrinogen which stayed stable or even increased during long-term treatment.
- Find related publications in this database (Keywords)
- cellular immune system
- neopterin
- fibrinogen
- atherosclerosis
- HELP therapy