Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Abrahamian, H; Ludvik, B; Schernthaner, G; Prager, R; Zellenka, U; Knudsen, L; Wascher, T.
Improvement of glucose tolerance in type 2 diabetic patients: traditional vs. modern insulin regimens (results from the Austrian Biaspart Study).
HORMONE METAB RES. 2005; 37(11): 684-689.
Doi: 10.1055/s-2005-870579
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- Co-Autor*innen der Med Uni Graz
- Wascher Thomas
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- Abstract:
- OBJECTIVE: Major advantages of modern insulin regimens containing premixed insulin analogues in comparison to traditional insulin regimens have not been evaluated yet. The aim of the present study was to investigate whether meal-related (breakfast, lunch, dinner) application of biphasic insulin aspart 30 (BIAsp 30) provides better glycaemic control than administration of biphasic human insulin 30 (BHI 30) twice per day. RESEARCH DESIGN AND METHODS: In a multi-centre, randomized, open-label parallel trial, a total of 177 patients with type 2 diabetes mellitus were exposed to the two different insulin regimens described above over a study period of 24 weeks. HbA1c and glycemic exposure parameters were measured at predefined intervals. RESULTS: The mean difference between treatment groups in HbA1c after 24 weeks of treatment was 0.08% (p = 0.6419). Analysing the 7-point blood-glucose (BG) profiles, significant differences in BG levels were observed after lunch (156 vs. 176 mg/dl, p = 0.0289), before dinner (142 vs. 166 mg/dl p = 0.006) and after dinner (154 vs. 182 mg/dl p = 0.002) in favour of BIAsp 30 insulin. Prandial BG increment was lower in the BIAsp 30 group at breakfast (p = 0.057) and lunch (p < 0.0005). No difference was found regarding safety parameters in the two treatment groups. CONCLUSIONS: This study demonstrates that meal-related BIAsp 30-insulin maintains postprandial BG control more effectively than traditional BHI 30 insulin twice per day in type 2 diabetic patients.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Blood Glucose - analysis
- Diabetes Mellitus, Type 2 - blood
- Drug Administration Schedule - blood
- Female - blood
- Glucose Tolerance Test - blood
- Hemoglobin A, Glycosylated - analysis
- Humans - analysis
- Insulin - administration and dosage
- Male - administration and dosage
- Middle Aged - administration and dosage
- Find related publications in this database (Keywords)
- type 2 diabetes mellitus
- insulin analogues
- premixed insulin formulations
- postprandial glucose
- meal-based insulin regimens