Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Schagerl, S; Lackner, H; Benesch, M; Kerbl, R; Schwinger, W; Dornbusch, HJ; Sovinz, P; Urban, C.
Prospective evaluation of neuroendocrine late effects after treatment of pediatric brain tumors
MONATSSCHR KINDERHEILK 2000 148: 251-256.
Doi: 10.1007/s001120070007
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- Co-Autor*innen der Med Uni Graz
- Benesch Martin
- Dornbusch Hans Jürgen
- Kerbl Reinhold
- Lackner Herwig
- Ritter-Sovinz Petra
- Schwinger Wolfgang
- Urban Ernst-Christian
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- Abstract:
- Purpose: The aim of the study was to evaluate the frequency and severity of neurologic and/or endocrine late effects after childhood brain tumors in order to initiate an adequate therapy in time.Patients and methods: 47 children,treated between January 1990 and December 1998, were entered into the present prospective study. 16 patients were treated by surgery alone, 10 patients had surgery followed by radiotherapy,15 patients had surgery combined with chemotherapy and radiotherapy and 6 patients received synchronous radiochemotherapy after surgery. At the end of treatment and subsequently at yearly intervals all patients were evaluated for neuroendocrine tumor- or treatment-related side effects.Results:The median duration of follow-up is 36 months (Range 2 to 100 months). 81% of the patients showed neurologic deficits, 29% of them already at diagnosis, 39% immediately after surgery and 32% following chemotherapy and/or radiotherapy. Improvement of neurologic deficits was observed in 45% of the patients within 5 years. Endocrine deficiencies were seen in 44%. In 8 patients these deficits were detected two or more years after cessation of oncologic therapy.Conclusion:There is a substantial number of neurologic and endocrine late effects in children surviving brain tumors. Prospective follow-up is mandatory to detect these deficits as early as possible and to start adequate treatment and training programs.
- Find related publications in this database (Keywords)
- brain tumors
- neurologic late sequelae
- endocrine late sequelae
- childhood