Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Widner, B; Leblhuber, F; Walli, J; Tilz, GP; Demel, U; Fuchs, D.
Tryptophan degradation and immune activation in Alzheimer's disease.
J Neural Transm. 2000; 107(3):343-353
Doi: 10.1007%2Fs007020050029
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Demel Ulrike
- Tilz Gernot
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Alzheimer's disease (AD) is likely associated with systemic immune activation. During immune response, interferon-gamma stimulates indoleamine 2,3-dioxygenase (IDO) converting tryptophan to N-formylkynurenine followed by kynurenine in an ensuing step. Thus, IDO activity is estimated by the kynurenine per tryptophan quotient (Kyn/Trp). In 21 patients suffering from AD, in 20 controls of similar age, and in 49 blood donors we measured serum tryptophan and kynurenine concentrations by HPLC. Lower tryptophan concentrations were found in elderly control subjects compared to blood donors (62.1 vs. 73.0 microM, p < 0.005). Tryptophan concentrations tended to be still lower in AD patients (54.4 microM, p = 0.07) compared to elderly controls. Enhanced tryptophan degradation in patients was reflected by significantly increased Kyn/Trp (46.1 vs. 34.1 in elderly controls, p < 0.05). Correlations were found in patients between Kyn/Trp and concentrations of soluble immune markers in serum, i.e., neopterin, interleukin-2 receptor and tumor necrosis factor receptor (all p < 0.001). Increased Kyn/Trp was associated with reduced cognitive performance. Tryptophan degradation due to immune activation may exert impact on the pathogenesis of AD.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Alzheimer Disease - immunology
- Brain - immunology
- Female - immunology
- Humans - immunology
- Interferon Type II - blood
- Kynurenine - blood
- Male - blood
- Middle Aged - blood
- Neopterin - blood
- Tryptophan - blood
- Find related publications in this database (Keywords)
- Alzheimer's disease
- tryptophan
- kynurenine
- kynurenine per tryptophan quotient
- immune activation
- soluble immune markers
- neopterin