Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Greinix, HT; Linkesch, W; Seifert, M; Kubista, E; Czerwenka, K; Elahi, F; Zielinski, C; Hoecker, P; Steger, G; Schulenburg, A; Neumeister, G; Rabitsch, W; Jakesz, R; Kalhs, P.
Paclitaxel-containing high-dose chemotherapy in high-risk breast cancer patients.
Acta Oncol. 2000; 39(1):47-52
Doi: 10.1080/028418600430969
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Greinix Hildegard
- Co-Autor*innen der Med Uni Graz
- Linkesch Werner
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- Abstract:
- Despite standard-dose adjuvant chemotherapy, the prognosis for patients with breast cancer and extensive axillary lymph node involvement at diagnosis is poor. The efficacy of a paclitaxel-containing, high-dose chemotherapy protocol in 21 high-risk breast cancer patients is assessed. After standard-dose chemotherapy followed by peripheral blood stem cell (PBSC) mobilization, high-dose therapy with paclitaxel, carboplatin, and cyclophosphamide and CD34-selected PBSC rescue was given. Hematologic reconstitution after high-dose therapy was rapid. Main toxicity included diarrhea grade I or II in about half of the patients and infections were observed in 19%. Five-year probabilities for relapse and failure-free survival were 32% and 62%, respectively. High-dose consolidation with paclitaxel, carboplatin, and cyclophosphamide achieves a high failure-free survival in patients with high-risk breast cancer with acceptable toxicities and stable, long-term hematopoietic reconstitution. Evaluation of the benefit of high-dose therapy in these patients in larger prospective, randomized trials is warranted and currently under way.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Antineoplastic Agents, Phytogenic - administration & dosage
- Antineoplastic Combined Chemotherapy Protocols - therapeutic use
- Breast Neoplasms - drug therapy Breast Neoplasms - pathology
- Carboplatin - administration & dosage
- Cyclophosphamide - administration & dosage
- Disease-Free Survival -
- Dose-Response Relationship, Drug -
- Female -
- Hematopoietic Stem Cell Transplantation -
- Humans -
- Middle Aged -
- Paclitaxel - administration & dosage
- Prognosis -
- Risk Factors -
- Treatment Outcome -